Clinical cases of Anemia Flashcards
Can be triggered by drugs, especially aspirin and anti-malarial drugs
G6PD deficiency
Cannot repair oxidative damage
G6PD deficiency
Directed against, and destroys gastric parietal cells, so that they cannot make intrinsic factor
Anti-parietal cell antibody
Presents with intense ischemic pain in the chest, back, abdomen, and bones due to occlusion of small vessels; fever; nausea and vomiting
Sickle cell anemia
Pernicious anemia can be caused by which of the following?
B12 deficiency Lack of Intrinsic factor Atrophic Gastritis Lack of absorption site Crohn's disease
Blood smear: microcytic spherocytes. Retics up to 20%
Heredity Spherocytosis
Presents with glossitis and/or diarrhea
Folate or B12 deficiency
In iron deficiency anemia, ferritin will be low and TIBC will be high. True or False?
True
Can present with glossitis, diarrhea, peripheral neuropathy (numbness and tingling in extremities), subacute combined degeneration of spinal cord (loss of position and vibration sense), positive Romberg test, ataxia, motor weakness, hyperreflexia, dementia, or psychiatric problems
B12 deficiency
Things that occur with high iron
Ferritin and TIBC
High Ferritin and Low TIBC
Macrocytic anemia caused by vitamin B12 and/or folate deficiency; interruption of DNA Synthesis
Megaloblastic anemia
96% of patients present by age 8 with painful crises; splenic sequestration.
Homozygous or Heterozygous
Homozygotes
Fish tapeworm can lead to competition for B12 and eventually cause?
Megaloblastic Anemia
Anemia of chronic disease
Normochromic normocytic anemia
Cell missing enzyme to maintain a normal shape. Fragile…life span 3 weeks instead of 4 months. Mild jaundice, gallstones, splenomegaly (10x normal)
Heredity Spherocytosis
