Inflammation

Question 1

Which cell is key in acute inflammation and which cells are key in chronic inflammation?

Answer 1

Acute inflammation: Neutrophils

Chronic inflammation: Lymphocytes, Plasma cells and histiocytes

Question 2

What are the 3 process that occur in the early stages of acute inflammation?

Answer 2

1. Changes in vessel calibre, and flow
2. Increased vascular permeability and formation of fluid exudate
3. Formation of cellular exudate - emigration of neutrophil polymorphs into the extravascular space

Question 3

What is a granulation tissue?

Answer 3

Granulation tissue is a combination of capillary loops and myofibroblasts.

Question 4

What is a granuloma?

Answer 4

A granuloma is an aggregation of epithelioid histiocytes. When macrophages are unable to destroy ingested organisms, the undergo differentiation into epithelioid cells.

Question 5

What is the difference between exudate and transudate?

Answer 5

Exudate have high protein content because they result from increased vascular permeability.
Transudate have low protein content because the vessels have normal permeability characteristics.

Question 6

What is Sarcoidosis?

Answer 6

A condition involving abnormal collections of inflammatory cells that form granulomas.

Question 7

Excessive exudate leads to?
Excessive necrosis leads to?
Persistent causal agent progresses into?

Answer 7

Excessive exudate causes suppuration.
Excessive necrosis leads to organisation and repair, and fibrosis.
Persistent causal agent progresses into chronic inflammation.

Question 8

Where are amyloids formed in amyloidosis?

Answer 8

In the extracellular space in tissue