Inflammation Flashcards

1
Q

Which cell is key in acute inflammation and which cells are key in chronic inflammation?

A

Acute inflammation: Neutrophils

Chronic inflammation: Lymphocytes, Plasma cells and histiocytes

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2
Q

What are the 3 process that occur in the early stages of acute inflammation?

A
  1. Changes in vessel calibre, and flow
  2. Increased vascular permeability and formation of fluid exudate
  3. Formation of cellular exudate - emigration of neutrophil polymorphs into the extravascular space
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3
Q

What is a granulation tissue?

A

Granulation tissue is a combination of capillary loops and myofibroblasts.

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4
Q

What is a granuloma?

A

A granuloma is an aggregation of epithelioid histiocytes. When macrophages are unable to destroy ingested organisms, the undergo differentiation into epithelioid cells.

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5
Q

What is the difference between exudate and transudate?

A

Exudate have high protein content because they result from increased vascular permeability.
Transudate have low protein content because the vessels have normal permeability characteristics.

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6
Q

What is Sarcoidosis?

A

A condition involving abnormal collections of inflammatory cells that form granulomas.

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7
Q

Excessive exudate leads to?
Excessive necrosis leads to?
Persistent causal agent progresses into?

A

Excessive exudate causes suppuration.
Excessive necrosis leads to organisation and repair, and fibrosis.
Persistent causal agent progresses into chronic inflammation.

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8
Q

Where are amyloids formed in amyloidosis?

A

In the extracellular space in tissue

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