Inflammation Flashcards
How long is acute inflammation?
Few hours to 6 weeks
How long is sub acute inflammation?
6 weeks to 3 months
How long is chronic inflammation?
3 months to decades
What are the effects of inflammation?
Allergic reactions
Degradtive:-dermatitis
-rheumatoid
Fibrotic scarring:
-asbestosis (Lung disease)
-sepsisWhat is inflammation?
A physiological response to any injury or infection
It mobilises the bodies defences and focuses them at the site of injury
What’s the process of inflammation?
Allergen—>formation of lgE antibodies—>binds to mast cells—>release of granules containing histamine—>histamine causes urticarial rash
Two types of injuries?
1.Internal: Immune Metabolic 2.external: Infection Physical Chemical Mechanical
Two types of inflammation responses?
Systemic
Local
Examples of inflammatory substances?(3)
Histamine
Prostaglandins
Leukotrienes
An example of a systemic response?
Fever
What does systemic mean?
All over the body
What does local mean?
In one place
When fever hits, what happens?
Destruction of bacteria—>releasing pyrogens
Pyrogens—>any substance that causes a fever
Your own body releases them
Acute phase reactions?
Fatigue Lack of appetite Nausea Low bp Acute phase proteins released
APP’s?
Acute phase proteins
Synthesised by liver, monocytes, or fibroblasts
2 groups:1.major apps
2.moderate APP’s
3 contents of APP’s
- C-reactive protein
- serum amyloid
- cysteine protease inhibitor
4 local events After injury
Neural injury
Vascular events
Enzymic cascades
cellular events
What happens in vascular events
Dilation of artierioles
Increased capillary permeability
Wheel + flare response
What happens in enzymatic cascades
Blood clots—>leads to lysis of bacteria
4 Cellular events?
1-migration ( migrate to damaged blood vessels)
2-margination (move to damage margins of the blood)
3-adhesion (stick to endothelium)
4-diapedesis (migration through wall of capillary or post capillary venule)
What’s the role of a mast cell?
Manufacture histamine from histidine
Storage in granules (heparin etc)
