inflammation Flashcards
what molecules attract PMNs
LTB4 c5a IL8
what is the function of the other leukotrienes
LTC4, LTD4, LTE4 - slow reacting substances of anaphylaxis mediate vasoconstriction, bronchospasm, inc vasc perm.
what complement proteins activate mast cells
c3a, c5a
What are the opsonins
c3b and IgG
describe the function of kinin
cleaves high MW kininogen to bradykinin –> vasodilation and inc vasc permeability, pain
what molecules are responsible for pain
PGE2, bradykinin
what molecule is responsible for fever
PGE2
what are the antiinflammatory cytokines
IL10 , TGFB
When do macros come into the picture
peak 2-3 days
susceptibility in CGD
inc suscpetbility to staph aureus, pseudomonas, serratia, nocardia, aspergillus all catalase + organisms
people with MPO deficiency are at inc risk for what
candida infections
what is the second signal for CD4 T cell activation
B7 on APC binds CD28 on CD4 helper T cells
TH1 cells secrete
IFN - activates macros, B cell class switching igM –> igG, inhibits class TH2
TH2 cells secrete
IL4 - b cell class switching to igE IL5 - eosinophil chemotaxis and class switch to IgA IL13
what is the secondary signal for CD8 T cell activation
IL2 from cd4 TH1 cells