inflammation Flashcards

1
Q

what molecules attract PMNs

A

LTB4 c5a IL8

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2
Q

what is the function of the other leukotrienes

A

LTC4, LTD4, LTE4 - slow reacting substances of anaphylaxis mediate vasoconstriction, bronchospasm, inc vasc perm.

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3
Q

what complement proteins activate mast cells

A

c3a, c5a

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4
Q

What are the opsonins

A

c3b and IgG

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5
Q

describe the function of kinin

A

cleaves high MW kininogen to bradykinin –> vasodilation and inc vasc permeability, pain

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6
Q

what molecules are responsible for pain

A

PGE2, bradykinin

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7
Q

what molecule is responsible for fever

A

PGE2

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8
Q

what are the antiinflammatory cytokines

A

IL10 , TGFB

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9
Q

When do macros come into the picture

A

peak 2-3 days

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10
Q

susceptibility in CGD

A

inc suscpetbility to staph aureus, pseudomonas, serratia, nocardia, aspergillus all catalase + organisms

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11
Q

people with MPO deficiency are at inc risk for what

A

candida infections

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12
Q

what is the second signal for CD4 T cell activation

A

B7 on APC binds CD28 on CD4 helper T cells

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13
Q

TH1 cells secrete

A

IFN - activates macros, B cell class switching igM –> igG, inhibits class TH2

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14
Q

TH2 cells secrete

A

IL4 - b cell class switching to igE IL5 - eosinophil chemotaxis and class switch to IgA IL13

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15
Q

what is the secondary signal for CD8 T cell activation

A

IL2 from cd4 TH1 cells

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16
Q

what are the signals for activation of a B cells

A

ag binding IgM or igD cd40 binds to CD40 L on helper T cell

17
Q

digeorge syndrome

A

T cell deficiency hypocalemia - lack of parathyroid glands heart abnormalities vessel abnormalities

18
Q

SCID is caused by many etiologies, but build up of what molecule is one major cause?

A

adenosine deaminase deficiency leads to inc adenosine and deoxyadenosine

19
Q

what causes x linked agammaglobulinemia

A

mutated bruton tyrosine kinase - disordered B cell maturation

20
Q

what are patients with x linked agammaglobulinemia suscpetible to

A

bacterial, enteroviruses, giardia need to avoid live vaccines

21
Q

what is hyper igM syndrome

A

mutated cd40 L secondary signal for class switching doesnt occur low igA, igG, IgE - recurrent pyogenic infections

22
Q

wiskott aldrich syndrome

A

thrombocytopenia, eczema, recurrent infections - defective cellular and humoral immunity bleeding is major cause of death

23
Q

c1 inhibitor deficiency

A

hereditary angioedema

24
Q

what does CREST stand for

A

calcinosis/ anticentromere antibodies raynauds esophageal dysmotility sclerodactyly telangiectasia

25
Q

antibodies in mixed CT disease?

A

u1 ribonucleoprotein

26
Q

What is a classic example of a “stable” cell type and what does this mean

A

liver tissue cells that are quiescent but can enter into S phase if needed

27
Q

when does “repair “ occur

A

when regenerative stem cells are lost or cells lack regenerative capacity

28
Q

scar formation consists of what process

A

type III collagen –> type I collagen - higher tensile strength