Inflammation Flashcards
1
Q
Arach. Acid Synthesis
A
- Linoleyl CoA (18:2)
- γ-Linoleyl-CoA (18:3)
- Dihomo (20:3)
- Arachinoyl CoA- (20:4)
2
Q
Desaturation reactions require which cofactors?
A
O2
NADH
Cyt b5 – desaturase
3
Q
COX fate
A
PG’s and TXA’s
4
Q
LOX fate
A
–> HPETE –> LT’s, Lipoxins, HETE
5
Q
Cyp450 Fate
A
–> epoxides –>** diHETE, HETE**
6
Q
PGE2 vs TXA2 (functions)
A
PGE is vasodolator and uterine contration promoter
TXA is a vasoconstrictor and platelet aggregator
7
Q
Arachidonic acid requires what for activation?
A
Hydroxylation of C-15
8
Q
Prostanoid signaling occurs via _____
A
GPCR’s
9
Q
Enzyme in platelets related to all this stuff?
A
Thromboxane Synthase
10
Q
COX1 vs COX2
A
COX1 is constitutive, involved in housekeeping of MOST tissues
COX2 is inducible (constitutive only in CNS)
11
Q
COX2-selective NSAID’s
A
Celecoxib and Rofecoxib (discont.)
