inflammation Flashcards

1
Q

what can steroids do to WBC

A

they can increase wbc

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2
Q

What is acute Inflammation

A

an early response to injury where chemical regulators call for more leukocytes (wbc) at the site of injury

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3
Q

What are the inflammatory sequence of events after getting cut?

A
  1. Arterioles constrict
  2. Mast cells and basophils release histamine
  3. arterioles dilate
  4. Hydrostatic pressure increases (swelling)
  5. Neutrophils “roll” along the surface of venules
  6. neutrophils migrate from vessels to interstitium (outside the vessel)
  7. chemotaxis causes neutrophils to migrate towards chemical indicators of injury
  8. phagocytosis
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4
Q

what are mast cells

A

they are cells in connective tissue that release histamine, cytokines and other chemicals as an immune response

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5
Q

During the inflammatory immune response, arterioles dilate. What happens as a result of this?

A

this causes redness and swelling in the area

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6
Q

What are neutrophils

A

a type of white blood cell that destroys pathogens by phagocytosis

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7
Q

how do steroids effect adhesion molecules and what is the result

A

steroids downregulate adhesion molecules which increases the amount of circulating neutrophils

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8
Q

what is diapedesis

A

the migration of neutrophils from in a vessel to the outside space of a vessel

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9
Q

what is the process of phagocytosis

A
  1. Opsonization
  2. ingestion
  3. destruction
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10
Q

what is opsonization

A

a process where antibodies mark the pathogen that will be targeted in phagocytosis

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11
Q

what is Bruton agammaglobulinemia

A

an X-linked disorder where opsonization can not occur

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12
Q

what is Chediak Higashi Syndrome

A

a disorder where phagolysosomes within cells cannot be formed therefore pathogens cannot be destroyed

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13
Q

what is Chronic Granulomatous Disease

A

the body cannot form superoxide free radicals causing recurrent infections

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