inflammation Flashcards
what can steroids do to WBC
they can increase wbc
What is acute Inflammation
an early response to injury where chemical regulators call for more leukocytes (wbc) at the site of injury
What are the inflammatory sequence of events after getting cut?
- Arterioles constrict
- Mast cells and basophils release histamine
- arterioles dilate
- Hydrostatic pressure increases (swelling)
- Neutrophils “roll” along the surface of venules
- neutrophils migrate from vessels to interstitium (outside the vessel)
- chemotaxis causes neutrophils to migrate towards chemical indicators of injury
- phagocytosis
what are mast cells
they are cells in connective tissue that release histamine, cytokines and other chemicals as an immune response
During the inflammatory immune response, arterioles dilate. What happens as a result of this?
this causes redness and swelling in the area
What are neutrophils
a type of white blood cell that destroys pathogens by phagocytosis
how do steroids effect adhesion molecules and what is the result
steroids downregulate adhesion molecules which increases the amount of circulating neutrophils
what is diapedesis
the migration of neutrophils from in a vessel to the outside space of a vessel
what is the process of phagocytosis
- Opsonization
- ingestion
- destruction
what is opsonization
a process where antibodies mark the pathogen that will be targeted in phagocytosis
what is Bruton agammaglobulinemia
an X-linked disorder where opsonization can not occur
what is Chediak Higashi Syndrome
a disorder where phagolysosomes within cells cannot be formed therefore pathogens cannot be destroyed
what is Chronic Granulomatous Disease
the body cannot form superoxide free radicals causing recurrent infections
