Inflammation

Question 1

5 steps of inflammation

Answer 1

1. Mast cell degranulation
2. Activate coag cascade
3. Activate kinin cascade
4. Release chemotactic factors
5. Activate compliment

Question 2

Complement system function

Answer 2

Bacteria lysis

Vasodilation

Trigger mast cell degranulation

Chemotaxis

Opsonisation

Question 3

Kinin function

Answer 3

Convert to bradykinin

Pain
Chemotaxis
Vasodilation
Vascular permeability

Question 4

Coagulation cascade

Answer 4

Activate kinin with factor 12 hageman factor

Question 5

Chemotaxis factors

Answer 5

Attract neutrophils, eosinophils, monocytes

All start phagocytosis

Question 6

Neutrophils vs monocytes

Who shows up to the inflammation party first?

Answer 6

Neutrophils first, 6 hours

Monocytes “stuck in traffic” 1-6 days

Both are phagocytes

They eat bad stuff and die(releasing acute phase reactants)