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Pathophysiology > Disorders Of Leukocytes > Flashcards

Disorders Of Leukocytes Flashcards

1
Q

Leukocytosis

A

Increase total WBC

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2
Q

Leukopenia

A

Decrease total WBC

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3
Q

Neutrophilia

A

Increase neutrophils

Bacteria/viral infection
Inflammation
Necrosis

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4
Q

Neutropenia

A

Decrease neutrophils

Liver disease
Cancer
Viral infection
Drugs

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5
Q

Eosinophilia

A

Increase eosinophils

Allergic reaction
Parasite infection

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6
Q

Eosinopenia

A

Decrease eosinophils

Steroid use
Pancytopenia

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7
Q

Basophilia

A

Increase basophils

Allergic reaction

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8
Q

Monocytosis

A

Increase monocytes

TB infection
Recovering from other infection

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9
Q

Monocytopenia

A

Decrease monocytes

Steroid use
HIV

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10
Q

Lymphocytosis

A

Increase lymphocytes

Viral infection
Lymphoma
Leukemia

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11
Q

Lymphocytopenia

A

Decrease lymphocytes

AIDS
Chemo
Steroid use

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12
Q

Acute lymphocytic leukemia

A

> 30% of lymphoblasts in blood or marrow

Genetic links

Child

Fever, pale, tired, joint pain, infection, splenomegaly, hepatomegaly, night sweat, weight loss, anemia, petechiae, bruising, thrombocytopenia

Headache, facial palsy, vomit, papilledema, menengial irritation

Survival rate decrease with age

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13
Q

Acute myleogenous leukemia

A

Immature myeloid cells

Genetic links

Aggressive and fast

Adult

Survival decrease with age

Fever, pale, tired, lymphadenopathy, infection, joint pain, splenomegaly, hepatomegaly, night sweats, weight loss, anemia, thrombocytopenia, petechiae, bruising

Headache, vomit, facial palsy, menengial irritation, papilledema

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14
Q

Chronic lymphocytic anemia

A

Malignant B-cells with decreased apoptosis.

Slow

Adults over 40

Survival 10+years

Suppression of humoral immunity, infections, neutropenia,

Most are asymptotic at time of diagnosis

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15
Q

Chronic myleogenous leukemia

A

Philadelphia chromosome

Adult over 40

Splenomegaly*

Hepatomegaly, hyperuricemia, infection, fever, weight loss

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16
Q

Hodgkin lymphoma

A

Epstine Barr virus

Reed Sternberg cells

White Men 15-35, over 50

Painless single neck lump

Fever, wt loss, night sweat, itchy

17
Q

Non Hodgkin lymphoma

A

NO reed sternberg

WIDESPREAD painless LUMPS

NO fever, night sweat, wt loss

60+yr, AIDS, hepC, immune suppression, organ transplant, H pylori, htlv virus, herpes8

Fam hx, chemical, radiation

18
Q

Multiple myeloma

A

Malignant plasma cells

Black, 60+, radiation, pesticide, monoclonal gammopathy

HYPERCALCEMIA (weak/tired/confused), NORMOCYTIC ANEMIA, bone tumor, renal failure

Survival 3 years

Infection, wt loss, bone pain/fractures

Pathophysiology (9 decks)

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