HIV Flashcards
HIV
3 enzymes
Reverse transcriptase
Integrase
Protease
Reverse transcriptase does what?
Make DNA from viral RNA
Integrase does what?
Viral DNA integrated into host DNA
Protease does what?
Maturation of viral proteins
HIV drug classes
Nucleoside reverse transcriptase inhibitors
Non nucleoside reverse transcriptase inhibitors
Protease inhibitors
Ccr5 inhibitors
Fusion inhibitors
Integrase inhibitors
AIDS CD4 count
Below 200
Always have aids diagnosis if cd4 drops below 200 just once
AIDS defining Illness
PCP MAC CMV Toxoplasmosis Kaposi sarcoma Lymphoma TB Oral thrush Progressive multifocal leukoencephalopathy Cervical cancer Histoplasmosis
Gold standard HIV test
4th generation combination immunoassay
HIV antibody and p24 antigen detection
10 days post infection
If result negative, they are negative
If positive, differentiate between type 1 or 2
Signs of HIV
Thrush Cervical dysplasia Cervical cancer Fiver 38.5X 1 month Oral leukoplakia Herpes ITP Pelvic inflammatory disease Peripheral neuropathy Vag yeast infections Kaposi sarcoma Opportunistic infection
PCP
Slow and progressive SOB Fatigue Night sweat Wt loss Poor appetite Cxr butterfly pattern infiltrates
Treat with Bactrim
MAC
Systemic infection
Fever
Night sweat
Wt loss
Lymphadenopathy
Clarithromycin and ethambutol for 6 months
CMV
Herpes virus
Infect retina
Cause blindness
Antiretroviral therapy side effects
Can cause
Insulin resistance and dyslipidemia
Children with HIV
Start antiretroviral immediately
Neg hiv test at 1 and 4 months is definitive
