Inflamation Flashcards

1
Q

What are the main cellular components in acute inflamation?

A

Neutrophils

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2
Q

What are the main cellular components in chronic inflamation?

A

Monocyes/MPH and Lymphocytes

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3
Q

Examples for vasoactive materials in acute inflamation

A

Histamine
Serotonine
Bradyknin
Leukotrians

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4
Q

Examples for chemotactic madiators in acute inflamation

A

Complement proteins (5ca)
Lymphotoxins Beta
Peptides

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5
Q

What is the immidiate response for cell injury?

A

Vasoconstriction

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6
Q

For how long does vasoconst. lasts?

A

Few seconds

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7
Q

What is the name for protein rich fluid in inflamation?

A

Exudate

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8
Q

Describe what is Transudate

A

Interstitial fluid accumulation caused by increased Hydrostatic P

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9
Q

Describe Leukocytes activation

A
  1. Chemoattraction
  2. Rolling-Adhesion
  3. Tight binding
  4. Transmigration
  5. Chemotaxins
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10
Q

Main events durring Chemoattraction

A

MPH release cytokines

Endot. cells express adhesion molecules

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11
Q

MPH release cytokines.

Which are they?

A

IL-1
TNF-a
Chemokines

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12
Q

Endot. cells express adhesion molecules.

Which arre they?

A

Selectins

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13
Q

Main events durring Rolling-Adhesion

A

Carbohydrate ligands on circulating Leukocytes binds to Selectin molecules

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14
Q

Main events durring Tight binding

A

Binding is mediated by ICAM proteins

Surface Integrins on Leukocytes become high-affinity

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15
Q

Main events durring Transmigration

A

Leukocytes cross the Endot. wall

Penetrate bsement memb. with help of hydrolytic enzymes

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16
Q

How do we call the movement od Leukocytes through the basement memb.?

A

Dipedesis

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17
Q

Main events durring Chemotaxins

A

Leukocytes move towards site of injury

Mediated by Chemokines and Chemoattractant

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18
Q

Types of acute inflammation

A
Serous
Fibrinous
Purulent
Hemorrhagic
Gangrenous
19
Q

Describe Serous inflammation

A
  • Exudate is watery and protein poor

- Fluid may derive from plasma orsecretion of mesothelial cells (lining pleura/pericardium)

20
Q

Examples for Serous inflammation

A

Endocarditis serosa

Meningitis serosa

21
Q

Describe Fibrinous inflammation

A
  • Consequence of more severe injury
  • Pseudomembranous inflammation
  • Fibrinous exudate may be dissolved by Fibrinolysis
  • Can lead to scarring if not removed
22
Q

Examples for Fibrinous inflammation

A
Fibrinous Pericrditis
Fibrinous Pleuritis
Fibrinous Peritonitis
Lobar Pneumonia
Pseudomembranous Colitis
23
Q

Describe Purulent inflammation

A
  • Large amounts of Purulent Exudate ( Pus= Neut, Necrotic cells, Edema fluids)
  • Abscesses (Focal cillections of Pus)
24
Q

Examples for Purulent inflammation

A

Purulent Pleuritis
Purulent Meningitis
Purulent Broncho-Pneumonia

25
Q

Describe Hemorrhagic inflammation

A
  • Damage to capillary Endot. integrity -> Bleeding

- Exudate usually contains blood

26
Q

Examples for Hemorrhagic inflammation

A

Hemorrhagic Tracheitis
Hemorrhagic Pneumonia
Hemorrhagic Enteritis
Anthrax

27
Q

Describe Gangrenous inflammation

A
  • Collection of activated MPH often with T cells
  • Sometimes associated with necrosis
  • Usually form of chronic infl.
28
Q

Examples for Gangrenous inflammation

A

Gangrenous Pneumonia

29
Q

Describe Empyema

A

Collection of Pus inside naturally existing cavity

30
Q

Possible outcomes of acute infl.

A

Scar formation
Regeneration and repair
Persistant infection or failure of healing -> chronic infl.

31
Q

Describe what is Subacute inflammation

A

Transition btw acute and chronic inflammation

32
Q

Another name to redness

A

Rubor

33
Q

Another name to warm

A

Calor

34
Q

Another name to Painful

A

Dolor

35
Q

Localized form of acute purulent inflammation forming a pus filled cavitiy

A

Abscess

36
Q

Pus in preformed cavity

A

Empyema

37
Q

Diffused form of acute purulent inflammation, spreading within a tissue

A

Phlegmon

38
Q

What is Granuloma

A

Small roundish aggregation of epitheloid MPH and giant cells

39
Q

Types of multinucleated giant cells?

A

Foreign body
Langerhans
Touton

40
Q

Example for Rheumatic granuloma

A

Aschoffs nodule

41
Q

Describe primary wound healing

A

Sterile
Cut wounds
Sharp edges

42
Q

Describe secondary wound healing

A

Damaged wounds
Loss of tissue
Infected wounds

43
Q

Phases of wound healing

A

Exudative
Resorptive
Proliferative
Reparative

44
Q

Proliferative phase of wound healing happens in day __

A

3