Inflamation Flashcards
What are the main cellular components in acute inflamation?
Neutrophils
What are the main cellular components in chronic inflamation?
Monocyes/MPH and Lymphocytes
Examples for vasoactive materials in acute inflamation
Histamine
Serotonine
Bradyknin
Leukotrians
Examples for chemotactic madiators in acute inflamation
Complement proteins (5ca)
Lymphotoxins Beta
Peptides
What is the immidiate response for cell injury?
Vasoconstriction
For how long does vasoconst. lasts?
Few seconds
What is the name for protein rich fluid in inflamation?
Exudate
Describe what is Transudate
Interstitial fluid accumulation caused by increased Hydrostatic P
Describe Leukocytes activation
- Chemoattraction
- Rolling-Adhesion
- Tight binding
- Transmigration
- Chemotaxins
Main events durring Chemoattraction
MPH release cytokines
Endot. cells express adhesion molecules
MPH release cytokines.
Which are they?
IL-1
TNF-a
Chemokines
Endot. cells express adhesion molecules.
Which arre they?
Selectins
Main events durring Rolling-Adhesion
Carbohydrate ligands on circulating Leukocytes binds to Selectin molecules
Main events durring Tight binding
Binding is mediated by ICAM proteins
Surface Integrins on Leukocytes become high-affinity
Main events durring Transmigration
Leukocytes cross the Endot. wall
Penetrate bsement memb. with help of hydrolytic enzymes
How do we call the movement od Leukocytes through the basement memb.?
Dipedesis
Main events durring Chemotaxins
Leukocytes move towards site of injury
Mediated by Chemokines and Chemoattractant