Cardiovascular Pathology Flashcards
Define Arteriosclerosis
Collective term for altered mechanic-stractual vascular wall characteristics (stiffening/softening)
Define Atherosclerosis
Mural change of elastic and middle sized to large muscular arteries
Define Arteriolosclerosis
Mural change of small muscular arteries and arterioles
Examples for degenerative vascular diseases
Arteriosclerosis
Vascular changes in diabetes mellitus
Aneurysms
Dissection of vascular wall layers
Two types of arteriolosclerosis
Hyaline arteriolosclerosis (homogenous) Hyperplastic arteriolosclerosis (onion like)- severe HTN
AMI is _____ necrosis of the ______
Coagulative
Myocardium
HTN is determined by
> 140/90 mmHg
Localization of MI by percentage
50% LAD
30% RCA
20% Cx
30 min - 4 h post AMI
What can we see?
Light microscope- relaxed muscle, wavy strings, glycogen depletion, cellular swelling
4- 12 h post AMI
What can we see?
Beginning of coagulative necrosis
Hyper eosinophilia
12-24 h post AMI
What can we see?
Contraction band necrosis
1-3 days post AMI
What can we see?
Progression of coagulative necrosis
Intensive Neut. infiltration
Loss of nuclei
Myocardial rupture occurs most likely within _________ after infarction
3 to 7 dyas
Morphology of MI
10-14 days
Red-gray infarct
Granulation tissue is well formed
Morphology of MI
2-8 weeks
Gray-white scar
Increased collagen deposition
Morphology of MI
2 months +
Dense collagenous scar
What is Dressler syndrome
Postinfarct Pericarditis
Aneurism of the left ventricle is mostly common in
Anterior and apical parts
Endocarditis usually involves ______
Valves
Infective endocarditis can be _____ or _____
Acute
Subacute
Non infective endocarditis can be (3)
Rheumatic Endocarditis
Endocarditis Marantica
Libman Sack Endocarditis (sterile)
Major criteria for Rheumatic fever
Joint involvement O (looks like heart) Pan-carditis Nodules, Subcutaneous Erythema Marginatum Sydenham chorea
Histology signs for Rheumatic fever
Anichkov giant cells Aschoff nodules Myocarditis Fibrinous exudate in pericardium Fibrinoid necrosis on the valves
Chronic Rheumatic fever affects mostly
Mitral valve 70%
Aortic valve 25%
