Infectious Mononucleosis Flashcards
def of infectious mononucleosis
a clinical syndrome with EBV infection
def of mononucleosis syndrome
non-EBV cause
what are non-EBV causes
HHV6
CMV
HSV1
who gets IM
adolescents
how severe is IM in children and adults
children - mild
adults - severe
which human herpes virus is EBV
HHV4
how is EBV transmitted
saliva (it is called the kissing disease)
less commonly genital secretions
where does IM affect
the throat initially
later on the infection spreads to the liver, spleen and lymph nodes
where is EBV found
it is ubiquitous
what are risk factors for EBV
kissing
sexual behaviour
how does IM present
non-specific symptoms such as malaise or fever
symptoms of pharyngitis (sore throat)
most commonly there will be tender lymphadenopathy
splenomegaly
investigations
1 bloods
-FBC (lymphocytosis and atypical lymphocytosis)
2 heterophile antibodies
-if negative but signs and symptoms indicate IM progress to:
3 EBVs-specific antibodies (sensitive and specific)
DDx for IM
group A streptococcal pharyngitis
what is the management for IM
supportive
- bed rest
- paracetomal
- NSAIDs
what should be given in addition in IM with upper airway obstruction or haemolytic anaemia or thromobytopenia
corticosteroids (prednisolone)
