Herpes Simplex Virus

Question 1

def

Answer 1

infection with HSV1 or HSV2

Question 2

which herpes virus is associated with oral ulcers

Answer 2

HSV1

Question 3

which herpes virus is associated with genital ulcers

Answer 3

HSV1 or HSV2

Question 4

what is more common HSV1 or 2

Answer 4

HSV1

Question 5

who commonly gets herpes

Answer 5

children

Question 6

what is the most common cause of genital ulcer disease

Answer 6

HSV2

Question 7

what sort of viruses are HSV

Answer 7

large enveloped dsDNA viruses

Question 8

pathophysiology

Answer 8

HSV1 and 2 are acquired with breaks in the skin
the virus replicates in the skin and then infects nerves and travels to the sensory ganglia where it enters a latent stage to evade the immune system
reactivation of the virus can cause asymptomatic shedding of the virus or symptoms of tingling, burning and ulceration

Question 9

what is HHV1

Answer 9

HSV1 - oral and genital herpes

Question 10

what is HHV2

Answer 10

HSV2 - genital herpes

Question 11

what is HHV3

Answer 11

varicella zoster virus (shingles and chickenpox)

Question 12

what is HHV4

Answer 12

infectious mononucleosis

burkitts lymphoma

Question 13

what is HHV5

Answer 13

CMV

Question 14

what is HHV8

Answer 14

kaposis sarcoma

Question 15

risk factors

Answer 15

HIV or immunsuppression

many sexual partners

Question 16

features of HSV

Answer 16

oral ulcers
genital ulcers

genital herpes associated with dysuria in women and lymphadenopathy

Question 17

what might a patient feel before an ulcer appears

Answer 17

tingling sensation

Question 18

investigations

Answer 18

1 viral culture shows HSV1 or HSV2
2 HSV PCR
3 igG assay
-type specific so can identify antibody to HSV1 or HSV2