Infectious Diseases LC Flashcards
List the current protease inhibitors available.
Major side effects?
Daru-navir, ataza-navir
S/E - long term cardiovascular S/Es (hyperlipidemia, insulin resistence), GI upset, hepatitis (darunavir)
Which HAART drugs needs to be given with a pharmacokinetic “booster”?
Name the boosters.
Protease inhibitors, elvitegravir (integrase inhibitor)
Boosters - cobicistat, ritonavir
List the current integrase inhibitors available.
Major side effects?
Dolute-gravir, Ralte-gravir, Elvite-gravir
BEST tolerated
S/Es - CNS effects (dizziness, insomnia, headache), nausea + rhabdo (Ralt), interactions (dolut; can’t use metformin)
List the current nucleoside reverse transcriptase inhibitors (NRTIs) available.
Major side effects?
Tenofo-vir, abaca-vir, emtricit-abine, zalcat-abine, zidovu-dine, lamivu-dine, stavu-dine
S/Es - mitochondrial toxicity (myopathy, peripheral neuropathy, lactic acidosis, pancreatitis)
Each have specific S/E profiles
S/E of abacavir
Myocardial infarction (prothrombotic) Hypersensitivity (HLAB5701)
Side effects of tenofovir alafenamide?
Side effects of tenofovir disoproxil fumerate?
TAF - hyperlipidemia, drug interactions
TDF - osteoperosis, nephrotoxicity
S/E of emtricitabine
Skin hyperpigmentation
Which NRTI has the highest risk of pancreatitis
Emtricitabine
List the current non-nucleoside reverse transcriptase inhibitors (NNRTIs) available.
Major side effects?
Efavirens, nevirapine, rilpirivine, etravirine
S/Es - SJS, hyperlipidemia
S/E of efavirine
Drug class?
Vivid dreams, nightmares and confusion
NNRTI
S/E of rilpiravine
Drug class?
QT prolongation
NNRTI
Which NNRTI is associated with hepatic necrosis?
Nevirapine
Which NRTIs causes lipodystrophy?
Zidovudine (AZT)
Stavudine
