Haem LC

Question 1

12 indications for allogeneic stem cell transplant

Answer 1

AML and ALL (major)

MDS
CML (relapse on imatinib)
CLL
Hodgkin lymphoma, NHL, Multiple myeloma (auto preferred)

Myeloproliferative diseases

Aplastic anemia, sickle cell anaemia, beta thalassemia major

Question 2

4 indications for autologous stem cell transplant

Answer 2

AML

Hodgkin lymphoma, Non hodgkin lymphoma, Multiple myeloma (preferred over allogeneic)

Question 3

Complications of allogenic stem cell transplant

Answer 3

Engraftment syndrome
Prolonged period to engraft
Febrile neutropenia
Cytopenias
GVHD (acute vs chronic)
Rejection
Graft failure Bacterial/fungal/viral infections

Question 4

Complications of autologous stem cell transplant

Answer 4

Engraftment syndrome
Prolonged period to engraft
Febrile neutropenia
Cytopenias
Graft failure
Relapse
Chemotherapy side effects
Bacterial infections