Infectious Disease Process Flashcards

0
Q

Interleukin - 2

A

Produced by CD 4 cells
Growth stimulator for T cells
Enhances activity of NK cells

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1
Q

What is interleukin 1 (IL-1)

A

Produced by many cell lines in the cellular immune system
Originally described as endogenous pylon - induces fever
Stimulates the differentiation if primitive T lymphocytes to specific T cell lines
Increases the production of other cytokines
Increases chemotaxis of macrophages

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2
Q

Interleukin 4

A

Produced by all T cells and mast cells

Stimulates growth of T and B lymphocytes, mast cells, & eosinophils

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3
Q

Interleukin-6

A

Produced ny macrophages, T & B lymphocytes
Promotes B lymphocyte differentiation
Causes proliferation of T lymphocytes
Causes differentiation of cytotoxic T lymphocytes, macrophages, and neutrophils
Induces fever

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4
Q

INH-a and INF B

A

Termed type I interferons

Produced by circulating WBC and fibroblasts
Interfere with the reproduction of viruses within infected cells

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5
Q

INF-y

A

Produced by activated T lymphocytes

Inhibits virus growth

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6
Q

Tumor necrosis factor (TNF)

A

Produced by macrophages

Causes involution and death of tumor cells

Causes protein catabolism in host with loss of muscle mass

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7
Q

Lymphotoxin

A

Similar to TNF
Promotes inflammation
Stimulates neutrophils

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8
Q

Granule yet macrophage colony stimulating factor (GM-CSF)

A

Produced by many cell lines

Stimulates reproduction of all granule the and macrophage cell lines

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9
Q

Granulocyte colony-stimulating factor (G-CSF)

A

Produced by many cells of the reticule endothelial system and vascular endothelium

Stimulates reproduction if granulocyte cell lines.

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10
Q

Monk the colony stimulating factor ( M-CSF)

A

Produced by many reticule endothelial cell lines

Stimulates reproduction of monocytes

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11
Q

Humoral immune system

IgG

A
Develop in a few weeks 
Provide long term immunity to a pathogen
Major circulating and Extra vascular antibody
immune response 
longest lived
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12
Q

Immunoglobulin M IgM

A

First reacting antibody to fight off infection
First line of defense
Present for only 6 months after exposure

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13
Q

IgA

A

Principle secretory antibody
Resides in mucous membranes
Found in saliva, breast milk, tissue of bladder, prostate, GI tract

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14
Q

IgD

A

Present on the surface of lymphocytes

Determines antigen specificity

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15
Q

IgE

A

Allergy

Releases large quantities of histamine & other inflammatory substances

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16
Q

What is aerobic

A

Microbes that must have oxygen to grow.

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17
Q

What is anaerobes ?

A

Microbes that grow without oxygen

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18
Q

What is facultative anaerobes?

A

Will use oxygen if present, but still grow I the absence of oxygen

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19
Q

What bacteria can penetrate the epithelium of the conjunctiva?

A

Neisseria gonorrhoeae, neisseria meningitidis, streptococcus pneumonia, listeria monocytogenes, corynebacterium Diphtheriae

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20
Q

What specimens are not appropriate for anaerobic cultures

A
Sputum
Rectal swab
Nasal or throat culture
Urethral swab
Voided urine
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21
Q

What is Virulence

A

Ability to invade and create disease in a host

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22
Q

Mast cells

A

Located in connective tissue and mucous membranes
When activated Excrete histamine and heparin
Histamine dilates blood vessels and causes neutrophils and macrophages to the site

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23
Q

What is a monocyte

A

Monocyte is the largest leukocyte which is a white blood cell
50% of monocytes are stored in the spleen

Quickly respond to infection & inflammation

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24
What is a neutrophil
First to arrive at the site of an infection most abundant phagocyte they inhibit the growth of bacteria or fungus
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What is an eosinophil
Active and killing bacteria and parasites | they also can cause tissue damage during allergic reaction
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What is the basophil
They are activated by pathogen and release histamine important defense against parasites Play a role in allergic reactions (such as cause asthma)
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Maternal passive immunity
Antibody mediated immunity IgG passed from mom to placenta Antibodies disappear between 6-12 month Transfer of IgA antibodies in breast milk
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What is antiserum injection
Passive immunity is acquired using antiserum injection- Injection contains antibodies form by a person or animal provide immediate but short-term protection against an example is hepatitis exposure or tetanus antitoxin
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What are parasites
Ectoparasites Protozoa Helminths Detected by microscopic examination
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Name the ectoparacites
Infestations are common in the community Can spread in healthcare facility Scabies, bedbugs, lice
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What are Protozoa
Unicellular free loving eukaryotic organisms Community health problems (not typical in health care facilities) Giardiasis Toxoplasma Giardiasis
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What is helminths
Parasitic worms Roundworms Tapeworms Flatworm
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Anthrax
``` Paused by bacillus anthracis biological agent Occupational contact or infected animals Incubation hours to 7 days typically 48 hrs Contact precautions Treatment with penicillin, Cipro ```
34
Aspergillosis
Fungal disease in resp tract of birds/mammals Diagnosed by intradermal or scratch test Days to weeks incubation No precautions Treated with corticosteroids.
35
Brucellosis mediterranean fever
Signs and symptoms fever headache weakness profuse sweating chills depression weight loss and aching Incubation 5 to 60 days use contact precautions
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Chickenpox
``` Herpes virus, varicella Fever, maculopaoular skin eruptions, Incubation 2-3 weeks Chickenpox- airborne isolation, Disseminated zoster - s ```
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Cholera
``` Infection of small intestine Watery stools Incubation 5 days Contact precautions 50% die is not treated within hours ```
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Conjunctivitis pink eye
Hemophilia influenza epidemic, streptococcus pnemoniae, neisseria meningitis Incubation 24-72 hours Contact precautions
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Hemorrhagic fever (break bone fever)
Infectious tropical disease caused by dengue virus | Incubation 3-14 days
40
Diphtheria
Corynebacterium Diphtheriae Bacterial disease up involving pharynx Incubation 2-5 days
41
Ehrlichiosis
Transmitted by a tick Fever, chills, malaise, headache, muscle joint pain, headache Standard precautions Treat with tetracycline
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Erythema infectious fifth disease
Childhood disease slapped cheek and lazy exanthema Human parvovirus Incubation 4-20 days Droplet precautions
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Hep A
Jaundice, fatique, and pain, loss of appetite, nausea Incubation 15-50 days Fecal / oral route HAVRIX vaccination IgM antibody appears first and then declines
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Hep B
Jaundice, fatigue, and pain, loss of appetite, nausea. HBSAG found in the blood 1-2 months after exposure Incubation 45-180 days Anti- HBc IgG life time marker for HBV infection
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Hep C
``` 70% asymptomatic Anti- HCV can be detected in 4-24 weeks Incubation 2 weeks to 6 months Transmission - blood, sexual, perinatal Standard precautions Treat INF2b and ribavirin ```
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Hep D
``` Occurs with confection with HBV Detection of HDV Low incidence in US Incubation 2-8 weeks HDV not sexually transmitted hep B vaccination provides immunity ```
47
Hep E
Non enveloped particle of The Calcivirus family Usually a benign disease Incubation 15-64 days Fecal oral route for transmission
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Histoplasmosis
Systemic primary lesions in lung Incubation 3-17 days usually 10 days Standard precautions
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Hiv
Fever, malaise, lethargy, anorexia, nausea, headache, sore throat ELISA measures antibody response Western blot is confirmatory test Detected 3 weeks to 6 months after exposure Incubation 1-3 months
50
Influenza
Types A B C Symptoms include fever headache sore throat cough a Myalgia Strains of flu are described by their geographical site of isolation the culture number and the year of isolation Incubation period is 1 to 3 days droplet precautions
51
Legionnaires disease
Symptoms include anorexia malaise headache rapid rise and fever with chills nonproductive cough abdominal pain diarrhea Incubation period is 2 to 10 days. standard precautions mortality is about 39%
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Lyme disease
Borerelia buefdorferi Incubation 3-32 days ELISA testing
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Malaria
Symptoms include fever chills sweats cough diarrhea respiratory distress headache shock renal and liver failure, encephalopathy, cerebral edema, coma, death Incubation period is 7 to 14 days if it's a blood it's two months quinine is a treatment
54
Measles rubella which is red measles
Signs and symptoms include fever conjunctivitis cough spots red blotchy rash which begins on the face Diagnostic and testing includes and IgM antibodies which are present 3 to 4 days after the rash Airborne isolation treatment can include me you know globin and IG
55
Bacterial meningitis
Sudden fever, headache, N, V, stiff neck, convulsions, Test CSF appears cloudy, test for blood cells, leukocyte, cell count, protein ^ sugar Neisseria meningitis - treat with Cipro.
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Viral meningitis
Occurs in July, August, sept <40 y.o. No mental impairment Viral cultures of CSF
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Haemophilus influenzae
Usually associated with Otis media or pharyngitis. Causes bacteria meningitis deafness occurs in 50% Incidence has decreased since HIb vaccination
58
Mononucleosis (Epstein Barr disease)
Human game herpesvirus Fever, sore-throat, splenomegly, lymphadenopathy IFA test for IgM & IgA Incubation 4-6 weeks
59
Mumps
Fever, swelling, tenderness of salivary glands Incubation 12-25 days avg 18 DROPLET from 9 days past onset of swelling Treatment - none
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Pediculosis LICE
Infested hair is fluorescent under UV light Incubation 7-10 days Contact precautions Ectoparasites - scabies, bedbugs, lice
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Pertussis
``` Bortella pertussis Cough has a crowing or high pitched sound Diagnosed by NP culture Incubation 6-20 days Droplet for at least 5 days ```
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Plague (pestis)
Fever, chills, malaise, myalgia, nausea, sore throat, headache Dx by bipolar staining, FA test, Incubation 1-7 days Droplet precautions for 72 hours until abx Clothing will be infested with fleas use insecticides
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Poliomyelitis
Poliovirus (enterovirus types 1,2,3 Flaccid paralysis. Fever, malaise, headache, nausea. Vomiting. Muscle pain, stiffness of neck Dx: virus in stool, CSF, oral secretions Incubation 3-35 days, average 7-14 days Contact precautions
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rabies
``` Virus rhabdovirus of genus Lyssavirus Vizsla encephalomyelitis, sudden onset of apprehension, headache, fever, malaise, Sensory changes, DX: brain tissue Incubation 9 days to 7years Contact precautions Intensive medical care ```
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Rocky Mountain spotted fever
Sudden onset Fever, malaise, deep muscle pain, severe headache, maculopaoular rash on extremities include palms and soles of feet, petechiae, and hemorrhages, Incubation 3-14 days Standard precautions
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RSV respiratory syncytial virus
Bronchiolitis & pneumonia in infants and children under 1 year DX - virus antigens viral RNA Isolation contact and droplet
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Rubella- German measles
Togavieidae, genus rubivirus Maculopaoular rash resembles measles, headache, malaise, conjunctivitis, Incubation 14-23 days, average 16-18 days Droplet for 7 days after rash development
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SARS
Cornponavirus SARS CoV Fever 100.4, headache, body ache, mild respiratory symptoms Incubation 10 days Droplet and contact precautions
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Scabies
``` Sarcoptes scabies Mite penetrates the skin Diagnosed by skin scrapping Incubation 2-6 weeks Contact precautions for 24 hours after treatment ```
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West Nile virus
80% asymptomatic Fever, myalgia, rash, nausea, vomiting, anorexia, malaise, DX: test for CSF 8 days after symptoms IgM Incubation 3-14 days Standard precautions
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Yellow fever
Sudden onset Fever, chills, headache, backache, generalized muscle pain, nausea , vomiting, Incubation 3-6 days Standard precautions Protect from Mosquitos
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What do natural killer cells do?
Do not destroy microbes, but destroy the compromised host cd,lx such as tumor cells or virus infected cells Not part of inflammatory response
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Active immunity
Host had an immunological response and produces cells that response Host produces own antibodies Active immunity persists for a long time - years
74
Passive immunity
Humoral immunity Host receives antibodies from another source. (Mom to baby 6-12 months) Immunity is short lived months/weeks Anti-serum injection IVIG pooled human immunoglobin (Kelli)