Diseases

Question 0

What are the signs and symptoms of CJD

Answer 0

Ataxia
Monclonic seizures
Visual & sensory deficits
Abnormal psychiatric behavior
Coordination deficients

Question 1

What are the two forms of CJD Creutzfeldt-Jakob disease

Answer 1

Two forms -
Sporadic 1 case per million
Familial type
New forms associated with contaminated meats

Question 2

How is CJD a diagnosed

Answer 2

Checking CSF for 14-3-3 protein

Question 3

Name 3 prion diseases

Answer 3

CJD
Gerstmann straussler scheunker syndrome
Fatal familial insomnia

Question 4

vCJD

Answer 4

Bovine to human transmission

^ incidence in United Kingdom (1980-1996 exposure)

Question 5

What tissues are known to be highly infectious for CJD?

Answer 5

Brain, dura mater, pituitary, eye

Low infectivity lung, liver, kidney, spleen, lymph nodes, CSF

Question 6

How to disinfect/ sterilize instruments used on CJD patient

Answer 6

No precleaning (enzymatic)
Chlorine provides inactivation of a prion

Sterilization at 132* for 60 min gravity. OR

134 C for 18 min on pre vac cycle

Clean the environment with beach 1:10 solution

Question 7

Study CSF a analysis in pg 17-

Answer 7

Meningitis
Increase protein
Glucose is decreased
Neutrophils go up if bacterial