Infectious Disease-Notes Flashcards
What are some clinical features of irritable bowel syndrome?
pain relieved by BM
onset of pain related to change in frequency of stool and/or character of stool
noticeable abdominal bloating
sensation of incomplete evacuation or diarrhea with mucus in it.
What is a workup for suspected infectious diarrhea, bloody diarrhea?
ELISA tests for Rotavirus, C diff, Salmonella
Look for ova/parasites in the stool. helpful for giardia, entamoeba histolytica, ancylostoma duodenale. must do 3 samples.
sometimes…a colonoscopy. Ex: Cdiff would show pseudomembranous colitis.
What is the usual treatment for infectious diarrhea?
regular diet
oral rehydration
Infant pt is febrile. You find that stool is positive for salmonella. Do you do LP, blood cultures?
Yes.
What are some causes of infectious diarrhea to look out for in HIV patients?
cryptosporidium parvum
CMV
MAC
What are some important features of cryptosporidium parvum diarrhea in HIV patients?
protozoa
chronic watery diarrhea
acid fast cysts
happens when CD4
What are some important features of CMV colitis in HIV patients?
chronic bloody diarrhea
giant cells with owl’s eye inclusion bodies
What are some important features of MAC colitis in HIV patients?
chronic watery diarrhea
CD4
Which antibiotics do you use to treat the following: C diff salmonella EPEC Entamoeba histolytica
C diff: metro/vanco
salmonella: cipro
EPEC: cipro
entamoeba histolytica: metro
Which antibiotics do you use to treat the following: shigella EIEC Vibrio Cholera Giardiasis Cryptosporidium
shigella: cipro EIEC: cipro cholera: tetracycline, azithromycin giardiasis: metro cryptosporidium: nitazoxanide
Fever and bloody diarrhea could be caused by what?
shigella Salmonella campylobacter EHEC E. histolytica
What are some important features of fever & bloody diarrhea caused by E. histolytica?
can mimic IBD, but will worsen with steroids
can cause a liver abscess
peripheral eosinophilia
charcot-leyden crystals in stool (from eosinophils)
treat with metronidazole
What are some causes of diarrhea that consist of no fever, no blood?
norovirus rotavirus ETEC (will ONLY see diarrhea as a symptom) EPEC (in infants) Cholera vibrio parahemolyticus (oysters) giardia cryptosporidium parvum clostridium perfringens bacillus cereus
What are some important things to know about giardia diarrhea?
fatty, smelly diarrhea
onset is 1-2 weeks later
use proper sewage
treat with metronidazole
If you have diarrhea + N/V…what do you have?
viral gastroenteritis
What’s the deal with tropic sprue?
chronic fatty diarrhea
blunting of villi with infiltration of lymphocytes, plasma cells, eosinophils
malabsorption, VB12/folate deficiency
can present years after a person was in the tropics
What’s the deal with trichinella?
present in undercooked pork
get watery diarrhea
treat with albendazole
Ascaris lumbricoides can present how? What is the treatment?
post-prandial abdominal pain or vomiting
can even cause pancreatic duct or bile duct obstruction if there is a heavy enough burden
tx: albendazole, pyrantel pamoate
Ancylostoma Duodenale?
cough, anemia, malabsorption, weight loss, eosinophilia
tx: mebendazole, pyrantel pamoate
Treatment for enterobius vermicularis?
mebendazole or pyrantel pamoate
What are some non-inflammatory food poisonings?
S. aureus (intense vomiting 24 hours)
B. cereus (vomiting and diarrhea), from bad rice
C. perfringens, profuse diarrhea, rewarmed meat.
Inflammatory food poisoning?
C. jejuni. undercooked chicken. superficial ulcers in colon
EHEC: undercooked hamburgers. look at mackonkey agar. worry about HUS.
Y. enterocolitica. RLQ pain, mimics appendicitis
What causes ascending paralysis? Descending paralysis?
Ascending paralysis: Guillan Barre
Descending paralysis: Botulism
Features of HUS?
diarrhea illness GI bleeding purpura and HTN microangiopathic hemolytic anemia schistocytes
What are some important things to know about salmonella typhi?
gallbladder is the reservoir, can cause necrotizing cholecystitis
red spots on belly
high fevers.
treat with cipro, ceftriaxone
What are some things to know about shigella dysenteriae?
severe bloody diarrhea, seen in children in developing countries
What’s the deal with necrotizing enterocolitis?
premature infants w/ reduced intestinal perfusion translocation of bacteria and gas into the bowel wall feeding intolerance (bilious emesis) abdominal distention decreased BS sepsis (low platelet count) hematochezia metabolic acidosis
w/u:
serial abdominal radiographs. see pneumatosis intestinalis
NG tube to suction
What is the treatment for necrotizing enterocolitis? Possible complications?
Tx: bowel rest
vanco, gent, metro
IVF
NG tube suction
surgery if: abdominal wall erythmea, air in portal vein, intestinal pneumatosis, pneumoperitoneum
complications: septic shock, strictures, short bowel syndrome, death