Infectious Disease Flashcards
What is the most common cause of neonatal septicemia
Group B Strep
Causes of occult bacteremia in neonates?
GBS
E. coli
Listeria
Staph aureus
Coag. neg staph and Candida = preterm
What are causes of occult bacteria in children?
Strep pneumo
Neisseria
Salmonella
S. aureus
Group A Strep
What is the workup for fever, leukocytosis and no obvious focus of infection?
Blood/urine Cx
CBC
CXR
LP if < 28 days, AMS or meningeal signs
Occult bacteremia
< 28 days = Amp and Gent +/- hospitalization
29-90 days = Low risk i.e. normal UA, WBC < 15k
High risk ceftriaxone, IV ampicillin if enterococcus or listeria
3-36 mo = Ceftriaxone if WBC > 15 or septic
5 year old boy presents with sudden onset of high fever, reddish-purple spots, rapidly progressing to shock.
Meningiococcemia
S/Sx of meningococcemia - N meningitidis (3)
Shock - endotoxin
Petechiae - purpura - ecchymoses
Adrenal hemorrhage/insufficiency
How do you treat meningococcemia?
IV penicillin
Vaccine!!!
Common opportunistic infections in HIV (5)
Toxoplasmosis
Cryptococcosis
PCP/jiroveci
MAC/MAI/kansasii
CMV
Toxo s/sx and treatment
Mononucleosis syndrome = Fever, LAD, HSM
Dx: antibodies
Tx: Pyrimethamine and sulfadiazine
*replace folic acid*
Cyrptococcosis - S/sx
Fungal lung infection
AIDS presentation = Subacute/chronic meningitis
Typical presentation = Fever, HA, malaise
How do you treat cryptococcosis?
Amphotericin B and Flucytosine
High rate of recurrence
How do you diagnose cryptococcosis?
ELISA
India ink + CSF = White halos (Yeast)
How does PCP present, how do you diagnose and treat it?
Bad pneumonia
CXR = interstitial infiltrates x2
DX: Methenamine silver staining or Giemsa stain
Tx: TMP/SMZ
How does MAC present? How do you dx and treat it?
Fever, malaise, weight loss, night sweats +/- abd. sx
Dx: Culture
Tx: Clarithromycine or Azithromycin + Rifampin or cipro etc.
What are 2 things rifabutin can do?
Dec. serum AZT and clarithromycin
Turn secretions orange
Who gets TMP/SMZ for PCP ppx?
CD4 < 200
Who gets rifabutin, or clarithromycin or azithromycin ppx for MAC?
CD4 < 50
How does CMV present? How do you dx and treat it?
Pneumonitis, retinitis, mono-like
ELISA
Enlarged cells with large intranuclear inclusions
Tx: None, IV foscarnet or ganciclovir
Dew drops on a rose petal
Chicken pox - hides in sensory ganglia cells
Crops of new clear vesicles - crust over
Multinucleated giant cells on Tzanck (herpes)
Koplik spots - grayish white spots in mouth
High fever, coryza rash, LAD
Rubeola (Measles)
Supportive Treatment
Who shouldn’t get the measles vaccine?
Pregnant women
TB
Immunocompromised
Allergy to eggs or neomycin
High fever
Mild URI
Cervical LAD
Small discrete raised lesions on trunk spreading to neck face and proximal extremities
Roseola
*Can trigger febrile seizures in young children*
When is rubella contagious?
1 week before rash appears to 1 week after it fades