Infectious disease 3 Flashcards
Clinical features of fusariosis
- immunocompromised patient
- inoculated from tap water or soil
- skin nodules + pulmonary disease + persistent fever
- mold
Treatment of fusariosis
amphotericin
Diagnosis of anaplasmosis
serology + peripheral blood smear examination showing intraleukocytic morale
Specific features of anaplasmosis
- leukopenia + high fever
Ehrlichiosis vector + location
- Lone star tick
- Southeast and south central US
Typhoid fever clinical features + lab features
- high fevers + abdominal pain + characteristic erythematous macular rash (rose spots)
- can have elevated LFTS
Lemierre’s disease other term
septic thrombophlebitis of the internal jugular vein
Lemierre’s disease clinical features
patient with hx of recent pharyngitis + then develops sepsis + neck pain/swelling/persistent fever (infection may extend to lateral pharyngeal space or involve carotid sheath) + cavitary lung lesions
Typical cause of lemierre’s disease
- anaerobic organism fusobacterium necrophorum
imaging of pulmonary aspergillosis
- nodules with or without cavitation + ground-glass infiltrates
- *halo sign (“nodules surrounded by ground-glass infiltrates)
other clinical feature of cdiff
right lower quadrant or lower quadrant abdominal pain
How to reduce VAP risk
- semi recumbent positioning
- oral antiseptics
- avoid PPIs
Necrotizing fasciitis clinical features
- commonly after surgery in a diabetic or immunocompromised patient
- *exquisite tenderness to palpation
- crepitus
- hemorrhagic blisters
First step in management of suspected nec fasc
surgery consult for debridement
Indication for PCP pox
CD4 greater than 200
Indication for toxo ppx
CD4 less than 100
Initial therapy of neutropenic fever
- anti-pseudomonal beta-lactam (cefepime OR zosyn)
- Addition of vancomycin IF
- Hemodynamic instability
- severe sepsis
- pneumonia
- positive blood cultures for a gram-positive organism
- suspected catheter-related infection
- skin or soft-tissue infection
Presentation of acute HIV
- mono-like syndrome (fever, lymphadenopathy, sore throat, athralgias)
- generalized macular rash
- GI symptoms
Management of acute HIV
- combination antiretroviral therapy
- notify partner and consider secondary ppx
- don’t wait until resistance and genotype testing is done because people are highly infectious and the regimen can be modified as needed after it comes back
Treatment of leptospirosis
Doxy or penicillin
Additional intervention needed after culture with streptococcus bovis
colonoscopy (anaerobe)
Additional intervention needed after culture with clostridium septicum
colonoscopy (anaerobe)
Additional intervention needed after culture with nontyphoidal salmonella
HIV test
Additional intervention needed after diagnosis of candidemia
ophthalmologic examination
CMV esophagitis EGD + biopsy features
EGD: sharply demarcated, linear ulcers in distal one third of esophagus
Bx: intranuclear inclusions
HSV EGD features
EGD: well circumscribed shallow ulcers
CMV esophagitis treatment
IV ganciclovir
legionella PNA clinical features
- relative bradycardia (would expect higher for degree of fever)
- no response to beta lactam abx or aminoglycoside abx **outbreaks in nursing homes
legionella PNA treatment
ONLY quinolone or macrolides
RMSF vs. ehrlichiosis
- Ehrlichiosis = leukopenia + rash starting on trunk + southeeastern and south central US
RMSF = rash starting on extremities
Centor criteria
tender anterior cervical LAD
*fever
tonsillar exudates
absence of cough
Infectious mono vs. Group A strep
mono = younger patient, fatigue, splenomegaly, posterior LAD
Epiglottitis clinical features
- SEVERE sore throat (out of proportion to findings on exam) + dysphagia
- may or may not have drooling and stridor
Work up of epiglottitis
IF stable (no stridor) – lateral neck x-ray
treatment of epiglottitis
CTX + vancomycin
disseminated gonorrhea presentation
- asymmetric migratory joint pain
- pustular lesions
cervicofacial actinomycosis clinical features
- mandibular swelling + can form abscesses, fistulas, and sinus tracts
- sulfur granules
treatment of cervicofacial actinomycosis
IV penicillin initially then oral penicillin for 6-12 months
Abx associated with a high risk of Cdiff
- quinolones
- clinda
- cephalosporins
- penicillins
treatment of complicated cystitis
quinolones
Problem with NAAT for chlamydia
- high rate of false-positive results within 3 weeks of treatment so you shouldn’t retest within this time period (it’s amplifying the dead organism)
Treatment of chlamydia in women
azithro OR doxycycline
Follow up of PNA
1) **IF high risk characteristics (age over 50, smoking history) – follow up CXR 7-12 weeks after treatment is recommended to document resolution and exclude underlying malignancy
2) smoking cessation counseling
3) PNA vaccination
Best way to reduce transmission of HSV between partners
- chronic antiviral suppression therapy (transmission can occur with asymptomatic shedding and during prodromal phases)
Schistosomiasis presentation
1) Urinary – hematuria, dysuria, frequent urination
2) Intestinal – diarrhea, abdominal pain
3) Hepatic – hepatomegaly, splenomegaly
Nocardia clinical features
- immunocompromised patients
- lung and brain abscesses
treatment of nocardiosis
bactrim
Mycoplasma pneumonia isolation precaution order
droplet
RSV isolation precaution order
contact
Heamophilus influenza isolation precaution order
droplet
Measles isolation precaution order
airborne
Medical term for genital warps from HPV
condyloma acuminata
What are condyloma lata?
manifestation of secondary syphilis
treatment of condyloma acuminata
topical therapy (trichloroacetic acid, podophyllotoxin)
clostridium perfringens gastrointestinal illness clinical features
- watery diarrhea + undercooked or unrefrigerated food
antibiotics for meningococcemia
3rd generation cephalosporin (CTX or cefotaxime) + vancomycin (added for pneumococcal infection until final culture results are available
what are the encapsulated organisms?
- neisseria meningitidis
- strep pneumo
- h influenza
Management of candida from respiratory culture
- no anti fungal treatment (rarely indicates invasive candidiasis, typically just bronchial tree colonization), no need to repeat respiratory culture
Treatment of histoplasmosis presenting as an asymptomatic nodule
- no treatment (anti fungal therapy has no effect on nodule)
histoplasmosis treatment
IF mild –> itraconazole
IF moderate or severe –> amphotericin
Management of patient with partner testing positive for syphilis
Treat empirically with single dose of penicillin
meaning of life
?
Common lab abnormalities of dengue fever
- leukopenia + thrombocytopeia
Treatment of symptomatic zenker divertiuclum
surgery
common cause of PNA in immunocompromised patients following prolonged hospitalization in early transplant period
- nosocomial infection from VRE, pseudomonas, staph, candida
* pseudomonas commonly colonizes hospital equipment
Yersinia pestis clinical features
- swollen and painful lymph nodules (bubo)
- high grade fever
- rapid progression to sepsis with PNA, meningitis, shock
Yersinia pestis (bubonic plague) treatment
- tetracyclines or streptomycin
Management of patient with exposure to bubonic plague patient
doxycycline
Management of asymptomatic candiduria (candida in urine culture) in patient with chronic indwelling catheter
- don’t treat, remove or exchange catheter
gram-positive bacilli in CSF + treatment
- listeria
- ampicillin or penicillin g
strep pneumo microbiologic classification
gram positive cocci
core features of fibromyalgia
diffuse MSK pain + tenderness on exam
Clinical features of chancre of primary syphilis
- recent intercourse
- develops at inoculation site (*can also be mouth or pharynx, anus)
- painless + indurated + nontender lymphadenopathy
Clinical features of septic pulmonary emboli
- multiple bilateral cavitary lesions
- typically due to right-sided infective endocarditis
Clinical features of AIDS-related lymphomas
- low Cd4 count + long standing HIV + class NHL presentation – B symptoms, extra nodal disease
- AIDS-related lymphomas are common in advanced HIV
Most common AIDS-related lymphomas
DLBCL and Burkitt lymphoma
Time it takes for tic to be attached prior to borrelia transmission
- 48 hours
CD4 count at which patients are at increased risk of pneumocystis infection
CD4 less than 200
Immune reconstitution inflammatory syndrome (IRIS) clinical features
- Patient diagnosed with HIV, started on HAART, then presents with infectious symptoms (due to unmasking of underlying infection)
Management of IRIS
- continue HAART
- Rule out underlying infection (sputum cultures, etc.)
Intertrigo clinical features
- erythematous plaques and erosions in skin folds of intertiginous areas (fungal infection)
DRESS presentation
- fever, generalized LAD, facial edema, diffuse morbilliform skin rash
Chikungunya virus clinical features
- fevers
- severe polyarthralgias
Malaria clinical features
- GI (vomiting, diarrhea) + anemia + thrombocytopenia + *cyclical fevers
Treatment of latent syphilis
- benzathine penicillin weekly x 3 weeks
First line for neurosyphilis
Penicillin G IV x 10-14 days
*CTX is second line
First line for tertiary syphilis
Penicillin G IM x 3 doses
First line for primary and secondary syphilis
Penicillin G IM x 1 dose
who needs prophylaxis for contacts of meningococcal disease
- close contacts + healthier workers with prolonged duration or exposure to respiratory secretions
- regardless of vaccination status