Infectious

Question 1

What drugs can cause acute interstitial nephritis?

Answer 1

Acute kidney injury after initiation of an antibiotic (cephalosporin, penicillin, ciprofloxacin, trimethoprim–sulfamethoxazole) should raise suspicion for acute interstitial nephritis

Question 2

How is drug induced acute interstitial nephritis diagnosed?

Answer 2

Here, the diagnosis is supported by pyuria and a urine culture without growth. Drug-induced acute interstitial nephritis is classically described as presenting with a triad of an allergic rash, fever, and eosinophilia; pyuria may not always be present. Drug-induced acute interstitial nephritis may present a few days or several weeks after exposure.