Infections of Lymphoid Tissues Flashcards
What are the major viral infections that impact lymphatic system?
Ebola, Chickungunya, Yellow fever, Dengue, Zika
What are the bacterial infections that cause regional lymphadenopathy?
Catch scratch disease, plague, rabbit fever
To what family of viruses do ebola and marburgvirus belong? What is their structure?
FIloviruses; Enveloped Helical -ssRNA
What are the five strains of Ebola?
Ebola virus (Zaire), Sudan virus, Taï Forest virus, Bundibugyo virus,. Reston virus
What are the first symptoms of Ebola infection?
Sudden onset of fever, fatigue, muscle pain, headache, and sore throat
What cells do Ebola virus infect?
Lymphoid cells and then endothelial cells
How are Togiviruses typically spread?
Mosquitos
To what family of viruses does Chickungunya belong?
Togiviruses
In what cells does chickungunya virus replicate?
FIbroblats, skeletal muscle progenitor cells, and myofibers
How does Chickungunya present?
Debilitating illness with high fever, petechial or maculopapular rash, headache, fatigue, nausea, vomiting, muscle pain, joint pain
How can chickunggunya be distinguished from Dengue?
Chick. is more likely to cause high fever, severe polyarthralgia, arthritis, rash and lymphopenia; Dengue more likely to cause neutropenia, thrombocytopenia, hemorrhage
To what family of viruses does Yellow Fever belong?
Flaviviruses
What is the course of dengue fever manifestation?
Symptoms begin 4-7 days after mosquito bite and last 3-10 days and include severe headache and pains in muscles and joints
What type of cells does dengue virus replicate in?
Mononuclear cells
When would Dengue Shock Syndrome develop?
Upon re-infection with another serotype
