Infection + Response Flashcards

1
Q

Define disease.

A

an illness or disorder of the body or mind that leads to poor health

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2
Q

Define communicable disease.

A

Disease caused by a pathogen that passes from infected individuals to uninfected individuals

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3
Q

Define pathogen and give examples.

A

A microorganism that causes disease like bacteria/viruses/protists/fungi

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4
Q

How can transmission of pathogens occur?

A

Air, Water, Direct contact

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5
Q

How do viruses reproduce?

A

Viruses reproduce rapidly by inserting their genetic material into host cells.
Once many copies have been made, the host cell may burst open releasing the viral particles which can go on to infect other cells

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6
Q

Give examples of viruses.

A

Measles, HIV and Tobacco mosaic viruses

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7
Q

What are the symptoms of measles and how can they spread and treatment?

A

Symptoms: Fever, Red rashes…. sometimes: brain damage/blindness

Spread by: Inhalation of cough/sneeze droplets

To treatment

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8
Q

What are the symptoms of HIV and how can they spread and treatment?

A

Symptoms: Flu-like symptoms, can develop to make the immune system so weak that it can’t fight any other disease (AIDS).

Spread by: Sexually or exchange of bodily fluids.

Treatment: No treatment

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9
Q

What are the symptoms of TMV and how can they spread and treatment?

A

Symptoms: Discoloration of leaves (affects chloroplasts), won’t grow bc no light caught for photosynthesis.

Spread by: Direct contact

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10
Q

How do bacteria cause damage?

A

Bacterial pathogens produce toxins that cause damage to cells and tissues directly

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11
Q

What are the examples of bacteria?

A

Salmonella, gonorrhea

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12
Q

What are the symptoms of salmonella and how can they spread and treatment?

A

Symptoms: Abdominal cramps, diarrhea, fever and vomiting.

Spread by: by bacteria ingested in food, or on food prepared in unhygienic conditions

Treatment: Poultry vaccinated against it, proper hygiene.

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13
Q

What are the symptoms of gonorrhea and how can they spread and treatment?

A

Symptoms: thick yellow discharge from penis/vagina, pain when urinating

Spread by: sexual contact

Treatment: Antibiotics but now there are antibiotic resistant strands, barrier methods

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14
Q

What are examples of fungi?

A

Rose black spot, athletes foot

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15
Q

What are the symptoms of Rose black spot and how can it spread and treatment?

A

Symptoms: Purple/black spots on leaves, leaves drop.

Treatment: spores carried by wind/water

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16
Q

What are the symptoms of malaria and how can they spread and treatment?

A

Symptoms: Reoccurring episodes of fevers.

Spread by: Mosquitos biting infected person, malaria passes into mosquito, bites another person and they get infected (vector)

Treatment:
prevented by draining area of still water so mosquitoes don’t breed, using insecticides, sleeping under mosquito net.

17
Q

What are examples of non-specific defense systems?

A

The skin- protective layer (dead cells) which pathogen can’t penetrate. and sebum, pathogens can’t enter, forms scabs

The nose- has mucus and hair, trapping pathogens

The trachea and bronchi- cillia covered in mucus, which wafts into throat so its swallowed into stomach

The stomach- acid kills bacteria

18
Q

What is the job of the non-specific defense systems?

A

To prevent pathogens from entering the body

19
Q

What is the job of the immune system?

A

after the pathogen has entered the body, the immune system prevents the infectious organism from reproducing and destroys it

20
Q

How do white blood cells defend against the pathogen?

A

Phagocytosis

Production of antibodies

Production of antitoxins

21
Q

Describe how phagocytosis can fight against pathogens.

A

WBC detects chemicals released from pathogen
Moves towards it
WBC ingests it, uses enzymes to destroy it

22
Q

Describe how production of antibodies can fight against pathogens.

A

Antibodies bind to pathogen and destroy, they are extremely specific

They also remain in the blood for a long time, so they can protect us in case of infection again

23
Q

Describe how production of antitoxins can fight against pathogens.

A

Some bacteria produce toxins, antitoxins stick to toxins and prevent then from damaging cells

24
Q

What is a vaccine?

A

Injecting small quantities of inactive forms of a pathogen into the body and WBCs detect the antigen

25
How do vaccines work?
The WBCs produce antibodies specific to the inactive form of the pathogen and produces lots of copies and form memory cells. The antibodies remain in the blood, so if ever infected with the pathogen the antibodies fight against it
26
What is herd immunity?
If a large number of the population are vaccinated, it is unlikely that an unvaccinated individual will become infected with the pathogen
27
What do antibiotics do?
Kill bacteria
28
Describe antibiotic resistance.
Antibiotics have been overused. Bacteria can have random mutation in their DNA which cause them to be resistant to the antibiotic, so the population of antibiotic-resistant bacteria increase and another antibiotic is needed.
29
Hoe can we prevent antibiotic resistance?
Doctors need to avoid the overuse of antibiotics, prescribing them only when needed – they may test the bacteria first to make sure that they prescribe the correct antibiotic Antibiotics shouldn't be used for viral infections Patients need to finish the whole course of antibiotics so that all the bacteria are killed and none are left to mutate to resistant strains Antibiotics use should be reduced in agriculture
30
What are painkillers?
Medicines which treat the symptoms of the disease
31
Describe the discovery of new drugs.
Digitalis (strengthen heart rate drug)- From foxglove Aspirin (painkiller)- willow tree bark Penicillin- Penicillium mold
32
When developing new drugs, what do they test for?
Toxicity – does it have harmful side effects? Efficacy – does the drug work? Dose – what dose is the lowest that can be used and still have an effect?
33
Preclinical Testing: The drug is tested on cells in the lab Efficacy and toxicity are tested at this stage Whole organism testing: The drug is tested on animals to see the effect in a whole organism Efficacy, toxicity and dosage are tested at this stage Clinical trials: The drug is tested on human volunteers first, generally with a very low dose then increased. This is to make sure it is safe in a body that is working normally The next stage is to test on patients with the condition: The patients are often split into two groups; one given the drug the other given a placebo. This is called a double-blind study – neither the doctor nor the patient knows if the patient is getting the placebo or the active drug