Infection Drugs Review

Question 1

MOA of acyclovir

Answer 1

Converted to inhibitor of viral DNA polymerase

Causes chain termination in replicating DNA

Question 2

What is Ceftriaxone

Answer 2

3rd gen cephalosporin, beta-lactam

Question 3

Treatment for meningococcal sepsis

Answer 3

Ceftriaxone

Question 4

MOA of clarithromycin

Answer 4

Inhibition of protein synthesis

Question 5

Doxycycline is never given

Answer 5

IV

Question 6

What does Clavulanic acid do in co-amoxiclav

Answer 6

creates inactive complex with beta lactase

Question 7

What is gentamicin

Answer 7

amino glycoside
Inhibits protein synthesis

Question 8

Trimethoprim

Answer 8

folate antagonist - inhibits bacterial dihydrofolate reductase
risk of teratogenicity in first trimester

Question 9

C diff treatment

Answer 9

Vancomycin

Question 10

Cellulitis treatment

Answer 10

Flucoxacilin

Question 11

Gentamicin ADR

Answer 11

nephrotoxicity
Ototoxicity

monitor serum aminoglycoside concentration

Question 12

DDI between trimethoprim and

Answer 12

Methotrexate

both folate antagonists
both inhibit DHFR

consequence = severe bone marrow suppression (myelosuppression)

Question 13

Nitrofurantoin MOA

Answer 13

affects protein synthesis

Question 14

Nitrofurantoin indications and ADR

Answer 14

UTI

brown urine
Pulmonary fibrosis
Hepatic disorders
Peripheral neuropathy
Haematological

Question 15

Avoid nitrofurantoin in

Answer 15

renal impairment <45mil/min eGFR
Pregnancy at term - risk of neonatal lhaemolysis

Question 16

management of lower UTI

Answer 16

nitrofurantoin - 1st line in pregnancy (and in Leicester due to resistance to trimethoprim)

Trimethoprim- 3 day course in non pregnancy women, 7 day in men