exemplify review S2-4

Question 1

Is plasma steady state reached quicker if the rate of infusion increases

Answer 1

No

Question 2

How is plasma conc of drugs affected by decreased P450 enzyme activity

Answer 2

Increases plasma concentrations as not broken down as quickly

Question 3

Steady state plasma conc will be reached in how many half lives

Answer 3

5

Question 4

How to calculate Vd that is apparent

Answer 4

dose/plasma conc
Divide by weight of Patient to calculate L/kg

Question 5

Which reaction is likely to occur during phase II metabolism

Answer 5

Glucoronidation and sulfication (conjugation reactions)

Question 6

thiazides effect on potassium

Answer 6

hypokalaemia

Question 7

do beta blockers directly impact potassium levels

Answer 7

no

Question 8

common furosemide ADR

Answer 8

increased LDL cholesterol

Question 9

common spironolactone ADR

Answer 9

hyperkalaemia
Impotence

Question 10

do loop diuretics impact cholesterol

Answer 10

yes increase LDL cholesterol

Question 11

Can labetalol be used during pregnancy

Answer 11

Yes

Question 12

Which CCB shows greatest selectivity for vascular smooth muscle

Answer 12

Amlodipine

Question 13

Effect of using codeine in someone with CYP2D6 deficiency

Answer 13

Decreased therapeutic effect, higher dose needed

Less active metabolite produced as codeine must be metabolised to active metabolite

Question 14

Those that can only tolerate a low dose statin may be offered what in addition as secondary prevention

Answer 14

Ezetimibe

(fenofibrate only in specialist circumstance due to increased risk of rhabdomyolysis)