Incorrect pharm qs

Question 1

What is the mechanism of action of N-acetylcysteine?

Answer 1

Replenishes body stores of glutathione

excess paracetamol deplenishes glutathione > needed to detoxify intermediate product of paracetamol metabolism (NAPQI) > stays in toxic form > hepatocyte death

Question 2

Mechanism of action of caffeine

Answer 2

blocks adenosine receptors

Question 3

MoA of methotrexate?

Answer 3

competitively inhibits dihydrofolate reductase

Question 4

MoA of allopurinol?

Answer 4

inhibits xanthine oxidase

Question 5

MoA of carbamazepine?

Answer 5

modulates sodium and calcium channels (in the CNS)

Question 6

What can be used to reverse heparin?

Answer 6

protamine sulphate (only partially affective against LMWF, fully against unfractioned)

reversal not usually needed due to short half life unless significant haemorrhage occurs

Question 7

What can be used to reverse DOACs? Specifically dabigatran?

Answer 7

beriplex

dabigatran = direct thrombin inhibitor > idarucizumab

Question 8

What is flumazenil?

Answer 8

benzo antagonist
reverse sedative effects of benzos, especially in overdose

Question 9

What is pyridostigmine?

Answer 9

long-acting ACEi for symptomatic myasthenia gravis

Question 10

What is tamsulosin? SEs?

Answer 10

alpha blocker for BPH
SEs: dizziness, sexual dysfunction