Important cytokines/(Secreted by, function) Flashcards
1
Q
IL-1
A
- Macrophages
- Causes fever, acute inflammation. activates endothelium to express adhesion molecules and induces chemokines secretion to recruit WBCs
2
Q
IL-6
A
- Macrophages
- Causes fever and stimulates production of acute phase proteins
3
Q
IL-8
A
- Macrophages
- Major chemotactic factor for neutrophils
4
Q
IL-12
A
- Macrophages
- Induces differentiation of T-cells into Th1 cells and activates NK cells
5
Q
TNF-alpha
A
- Macrophages
- Mediates septic shock. Activates endothelium. Causes WBC recruitment and vascular leak
6
Q
IL-2
A
- All T cells
- Stimulates growth of helper, cytotoxic, and regulatory T cells, and NK cells
7
Q
IL-3
A
- All T cells
- Supports growth and differentiation of bone marrow stem cells. Functions like GM-CSF
8
Q
Interferon-gamma
A
- Th1 cells
- Secreted by NK and T cells in response to IL-12 from macrophages; stimulates macrophages to kill phagocytosed pathogens. Inhibits differentiation of Th2 cells
9
Q
IL-4
A
- Th2 cells
- Induces differentiation of T cells into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG
10
Q
IL-5
A
- Th2 cells
- Promotes growth and differentiation of B cells. Enhances class switching to IgA. Stimulates growth and differentiation of eosinophils
11
Q
IL-10
A
- Th2 cells and regulatory T cells
- Attenuates inflammatory response. Decreases expression of MHC class II and Th1 cytokines. Inhibits activated macrophages and dendritic cells.
