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Immunology > Immunopharmacology (Name)/Mechanism of action and Uses > Flashcards

Immunopharmacology (Name)/Mechanism of action and Uses Flashcards

1
Q

Cyclosporine

A
  • Calcineurin (cytoplasmic phosphatase) inhibitor; binds cyclophilin blocking T-cell activation by preventing IL-2 transcription
  • Transplant rejection prophylaxis, psoriasis, rheumatoid arthritis
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2
Q

Tacrolimus

A
  • Calcineurin (cytoplasmic phosphatase) inhibitor; binds FK506 binding protein (FKBP) blocking T-cell activation by preventing IL-2 transcription
  • Transplant rejection prophylaxis especially in renal and liver transplants
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3
Q

Sirolimus (Rapamycin)

A
  • mTOR inhibitor; binds FKBP blocking T-cell activation and B-cell differentiation by preventing response to IL-2
  • Kidney transplant rejection prophylaxis
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4
Q

Daclizumab and basiliximab

A
  • Monoclonal antibodies that block IL-2R

- Kidney transplant rejection prophylaxis

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5
Q

Azathioprine

A
  • Antimetabolite precursor of 6-mercaptopurine inhibiting lymphocyte proliferation by blocking nucleotide synthesis
  • Transplant rejection prophylaxis, rheumatoid arthritis, Crohn disease, glomerulonephritis and other autoimmune conditions
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6
Q

Mycophenolate mofetil

A
  • Reversibly inhibits IMP dehydrogenase, preventing purine synthesis of B and T cells
  • Transplant rejection prophylaxis and lupus nephritis
  • Used also as adjunctive to cyclosporine permitting reduction of cyclosporine dose and limiting toxicity
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7
Q

Corticosteroids

A
  • Inhibit NF-kapa B suppress both B and T cell function by decreasing transcription of many cytokines. Induce apoptosis of T lymphocytes
  • Transplant rejection prophylaxis and many autoimmune and inflammatory disorders
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8
Q

Aldesleukin

A
  • Recombinant IL-2

- Renal cell carcinoma and metastatic melanoma

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9
Q

Epoetin alfa

A
  • Recombinant erythropoietin

- Anemias (especially in renal failure)

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10
Q

Filgrastim

A
  • Recombinant G-CSF

- Recovery of bone marrow

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11
Q

Sargramostim

A
  • Recombinant GM-CSF

- Recovery of bone marrow

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12
Q

IFN-alpha

A
  • Recombinant cytokine

- Chronic hepatitis B and C, Kaposi sarcoma, malignant melanoma

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13
Q

IFN-beta

A
  • Recombinant cytokine

- Multiple sclerosis

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14
Q

IFN-gamma

A
  • Recombinant cytokine

- Chronic granulomatous disease

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15
Q

Romiplostim and eltrombopag

A
  • Recombinant thrombopoietin receptor agonists

- Thrombocytopenia

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16
Q

Oprelvekin

A
  • Recombinant IL-11

- Thrombocytopenia

17
Q

Alemtuzumab

A
  • CD52 Ab

- CLL and multiple sclerosis

18
Q

Bevacizumab

A
  • VEGF Ab

- Colorectal cancer and renal cell carcinoma

19
Q

Cetuximab

A
  • EGFR Ab

- Stage IV colorectal cancer and head and neck cancer

20
Q

Rituximab

A
  • CD20 Ab

- B-cell and non-Hodgkin lymphoma, CLL, Rheumatoid arthritis and ITP

21
Q

Trastuzumab

A
  • HER2/neu Ab

- Breast cancer

22
Q

Adalimumab, certolizumab and infliximab

A
  • Soluble TNF-alpha Ab

- IBD, rheumatoid arthritis, ankylosing spondylitis and psoriasis

23
Q

Eculizumab

A
  • Complement protein C5 Ab

- Paroxysmal nocturnal hemoglobinuria

24
Q

Natalizumab

A
  • Alpha4-integrin Ab

- Multiple sclerosis and Crohn disease

25
Q

Abciximab

A
  • Platelet glycoprotein IIb/IIIa

- Anti-platelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

26
Q

Denosumab

A
  • RANKL Ab (inhibits osteoclast maturation)

- Osteoporosis

27
Q

Digoxin immune Fab

A
  • Digoxin Ab

- Antidote for digoxin toxicity

28
Q

Omalizumab

A
  • IgE Ab (prevents IgE binding to Fc-epsilon-RI)

- Allergic asthma

29
Q

Palivizumab

A
  • RSV F protein Ab

- RSV prophylaxis for high risk infants

30
Q

Ranibizumab and bevacizumab

A
  • VEGF Ab

- Neovascular age-related macular degeneration

31
Q

Muromonab

A
  • Monoclonal antibody that targets CD3

- Treatment of acute kidney transplant rejection

32
Q

Anti-D immunoglobulin

A
  • Human IgG Abs to red cell D antigen (rhesus antigen)
  • Administer to Rh -ve mother within 72 hrs of Rh +ve delivery to prevent hemolytic disease of newborn in subsequent pregnancy

Immunology (10 decks)

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