Cells type/Cell surface proteins

Question 1

All nucleated cells

Answer 1

MHC I

Question 2

Naive T cells

Answer 2

• TCR (binds antigen-MHC complex)
• CD3 (associated with TCR for signal transduction)
• CD28 (binds B7 on APC)
• CXCR4/CCR5 (co-receptor for HIV)

Question 3

Helper T cells

Answer 3

• TCR (binds antigen-MHC complex)
• CD3 (associated with TCR for signal transduction)
• CD28 (binds B7 on APC)
• CXCR4/CCR5 (co-receptor for HIV)
• CD4, CD40L

Question 4

Cytotoxic T cells

Answer 4

• TCR (binds antigen-MHC complex)
• CD3 (associated with TCR for signal transduction)
• CD28 (binds B7 on APC)
• CXCR4/CCR5 (co-receptor for HIV)
• CD8

Question 5

Regulatory T cells

Answer 5

• TCR (binds antigen-MHC complex)
• CD3 (associated with TCR for signal transduction)
• CD28 (binds B7 on APC)
• CXCR4/CCR5 (co-receptor for HIV)
• CD4, CD25

Question 6

B cells

Answer 6

• Ig (binds antigen)
• CD19, CD20, CD21 (receptor for EBV), CD40
• MHC II, B7

Question 7

Macrophages

Answer 7

• CD14 (receptor for PAMPs, eg, LPS), CD40
• CCR5
• MHC II, B7 (CD80/86)
• Fc and C3b receptors (enhanced phagocytosis)

Question 8

NK cells

Answer 8

CD16 (binds Fc of IgG), CD56 (unique marker for NK)

Question 9

Hematopoietic stem cells

Answer 9

CD34