Important Cytokines Flashcards
IL-1 (secreted by and function)
Secreted by: Macrophages
Function: Endogenous pyrogen - causes fever, acute inflammation; activates endothelium to expression adhesion molecules
IL-6 (secreted by and function)
Secreted by: Macrophages
Function: Endogenous pyrogen - causes fever and production of acute-phase reactants
IL-8 (secreted by and function)
Secreted by: Macroaphages
Function: Major chemotactic factor for neurotphils
IL-12 (secreted by and function)
Secreted by: Macrophages (also by Bcells)
Function: Induces differentiation of TA cells into TH1 cells - activates NK cells
TNF-a (secreted by and function)
Secreted by: Macrophages
Function: Mediates septic shock, activates endothelium, causes leukocyte recruitment, vascular leak
IL-3 (secreted by and function)
Secreted by: All T-cells
Function: Supports growth and differentiation of bone marrow stem cells - functions like GM-CSF
IL-2 (secreted by and function)
Secreted by: TH1 cells
Function: Stimulates growth of helper and cytotoxic T-cells
Interferon-gamma (secreted by and function)
Secreted by: TH1 cells
Function: Activates macrophages and TH1 cells; suppresses TH2 cells; has anti-viral and anti-tumor properties
IL4 (secreted by and function)
Secreted by: TH2 cells
Function: Induces differentiation into TH2 cells; promotes growth of B cells; enhances class switching to IgE and IgG
IL-5 (secreted by and function)
Secreted by: TH2 cells
Function: Promotes differentiation of B cells; enhances class switching to IgA; stimulates growth and differentiation of eosinophils
IL-10 (secreted by and function)
Secreted by: TH2 cells (also secreted by regulatory T-cells)
Function: Modulates inflammatory response; inhibits actions of activated T cells and TH1; activates TH2
What cytokines do macrophages secrete?
IL-1, IL-6, IL-8, IL-12, TNF-a
What cytokine is secreted by ALL T-cells?
IL-3
What cytokines do TH1 cells secrete?
IL-2, interferon-gamma
What cytokines do TH2 cells secrete?
IL-4, IL-5, IL-10
