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Uveitis > immunosupressive drugs > Flashcards

immunosupressive drugs Flashcards

1
Q

MTX - when effect

A

3-6 weeks

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2
Q

MTX - side effects

A

myelosupression, hepatotoxicity or fibrosis, pneumonitis

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3
Q

cyclosporine - side effects

A

nephrotoxic, HTN

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4
Q

cyclosporine - mechanism

A

inhibits celcineurin and T cell, IL-2

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5
Q

MTX - mechanism

A

prevents conversion of dihydrofolate to tetrahydrofolate by irreversibly binding to DHFR

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6
Q

cyclophosphamide - mechanism

A

forms DNA cross at guanine positions

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7
Q

cyclophosphamide - side effects

A

bone marrow suppresion, hemorrhagic cystitis, alopecia

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8
Q

TNF inhib - side effects

A

lupus-like syndrome, exacerbate MS

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