Immunosuppression Therapy Flashcards
What does Azathioprine break down into and by what compound
Mercaptopurine
(Thiopurine Methyltransferase)(TPMT)
What does Azathioprine do
inhibits the repair and making of DNA
What needs to be monitored before administering Azathioprine
TPMT
If there is not a lot of it in
—> there will be a lot of Azathioprine
——> causes toxicity
What does Azathioprine toxicity cause
Myelosuppression
(bone marrow supression)
—–> fewer blood cells
Side effects of Azathioprine
- Teratogenic
- Nausea
- Neutropenia
- Hypersensitivity
Hypersensitivity when taking Azathioprine
- malaise
- dizziness
- fever
- hypotension
Neutropenia when taking Azathioprine
- sore throat
- bruising
- bleeding
How to treat Azathioprine induced nausea
resolves over time
Azathioprine monitoring
- TPMT levels
- liver function
- full blood count
How often should you monitor full blood count
weekly for 4 weeks
—-> then at least every 3 months
Which medication interacts with Azathioprine where you should stop immediately and what does it cause
ACEi
increases risk anaemia
Which medication interacts with Azathioprine where you should reduce the dose of Azathioprine and why
Allopurinol
increases risk of haematological toxicity
