Immunosuppressants/Cancer Chemo

Question 1

Immunosuppressant drugs

Answer 1

Glucocorticoids

Cyclosporine

Tacrolimus

Question 2

How immunosuppressants work

Answer 2

Inhibit cytokine production/action

Block cytokine receptors on immune cells

Drugs that inhibit DNA and RNA synthesis

Question 3

Immunosuppressant uses

Answer 3

Rheumatoid arthritis
Organ transplant
Chrohns disease

Question 4

Which immunosuppressant drugs are cytokine production inhibitors

Answer 4

Cylosporine
Tacrolimus

Both compounds reduce interleukin-2 synthesis

(remember, cytokines are crucial in T-lymphocyte proliferation)

Question 5

Cylosporine (cytokine production inhibitor)

Answer 5

Used in the prevention of kidney, liver, heart, and bone marrow transplant rejection.

may be used for other autoimmune disorders

risk of kidney damage

Question 6

Tacrolimus (cytokine production inhibitor)

Answer 6

Used for organ rejection prevention in liver and kidney transplantation

used in treatment of active rheumatoid arthritis

Question 7

Glucocorticoids (inhibits cytokine gene expression)

Answer 7

inhibits cytokine gene expression
drug mimics cortisol
In group “prednisone”

Inhibits synthesis of many cytokines

Question 8

Drugs that inhibit DNA and RNA synthesis

Answer 8

Azathioprine

mycophenolate mofetil