Immunosuppressants

Question 1

What are the cox 1/2 cyclooxygenase inhibitors?

Answer 1

Naproxen 
Ibuprofen 
Nabumetrone 
Indomethacin 
Ketorolac 
Aspirin

Question 2

What are the cox 2 specific inhibitors?

Answer 2

Celecoxib

Rofecoxib

Question 3

What is the cox 2 mechanism of action?

Answer 3

inhibits cox 2

Question 4

What are the 5-lipooxygenase inhibitors and what is their mechanism of action?

Answer 4

Zilueton
It works by inhibiting synthesis of Leukotrienes, which are involved in bronchocostrictin.

USED FOR ASTHMA

Question 5

Name the Leukotriene antagonists and their MOA..

Answer 5

Montelukast
Zafirlukast

They work by competitively inhibiting leukotrienes.

Zafir climbs the mountain to look

Question 6

What are the four Corticosteroids and how do they work?

Answer 6

Prednisone, Hydrocortisone, Dextramethasone, Prednisone

They work by entering the cell, binding to receptors, entering the nucleus and suppressing transcription

Question 7

What is the significance of Lipocortin?

Answer 7

It suppresses the action of phospholipase A2. Corticosteroids increase Lipocortin to stop production of A.A.

Question 8

What are the calcineurin inhibitors and their MOA

Answer 8

They are Cyclosporin and Tacrolimus– they inhibit t-cell production via APC pathway

Question 9

Wha are the toxicities of calcineurin inhibitors?

Answer 9

non-hogdkin lymphoma .

Question 10

What does -Ib indicate

Answer 10

inhibitor

Question 11

Which drug inhibits signaling through IL-2 pathway?

Answer 11

Tofacitenib— it works by ihnbiting JAK stat pathway than that is stimulated by IL2

Question 12

Name the anti-TNF antibody drugs and their MOA.

Answer 12

Etancercept(mab-like), Infliximab, Adalimumbab. They are cytokine antibodies, attached directly the cytokines.

Question 13

Name the anti-IL5 drugs..

Answer 13

Mepolizumab, used for eosinophilic asthma

Question 14

Name the anti IL6 dugs…

Answer 14

Tocilizumab

Question 15

Which drugs inhibit purine synthesis?

Answer 15

Azathioprine- associated with cancer!!!!

Mycophenolate – they are a similar structure and are incorporated into DNA chain

Question 16

What is Methotrexate’s MAO?

Answer 16

competitive inhibitor of folate, binds to DHFR, inhibits folic acid snythesis, inhibits purine synthesis, inhibits DNA synthesis —–

NOT BE USED WITH PREGNANT WOMEN

Question 17

What is DHFR?

Answer 17

Dihydrofolate reductase

Question 18

What are the three drugs that should not be used in pregnancy?

Answer 18

Azathioprine, Mycophenolate, Methotrexate

Question 19

What class of drug is Sirolimus and the MOA ?

KNOW THIS

Answer 19

It is a mTor inhibitor

• block IL-2 pathway (m-tor) therefore suppressing t-cell proliferation

Question 20

What doe Rituximab target?

Answer 20

CD20 B-cell receptor

Question 21

What drug binds to the IL-1 receptor?

Answer 21

Anakinra

Question 22

Which drug has decreased absoroption in older patients

Answer 22

Mycophenolate, tacrolimus, prednisone

Question 23

Name the drugs that are used in supressing the rejection of organs?

Answer 23

Cyclosporin, Tacrolimus, Azathiprine, Sirolumus, Rituximab

Question 24

Which drugs are associated with non-hodgekins lymophoma

Answer 24

The calcineurin inhibitors- cyclosporin and tacrolimus

Question 25

What is the function of Sirolumus

Answer 25

It is an Mtor inhibitor

Question 26

Name the drugs that suppresses IL-6, and what class it falls in:

Answer 26

Tocilizumab, antibodies

Question 27

Which drugs are associated with nephrotoxicities?

Answer 27

Cyclosporin and Tacrolimus

Question 28

Which drug kinds to the CD20 receptor?

Answer 28

Rituximab

Question 29

What is the IL-6 binding antibody?

Answer 29

Tocilizumab