Immunosuppressants Flashcards
What are the cox 1/2 cyclooxygenase inhibitors?
Naproxen Ibuprofen Nabumetrone Indomethacin Ketorolac Aspirin
What are the cox 2 specific inhibitors?
Celecoxib
Rofecoxib
What is the cox 2 mechanism of action?
inhibits cox 2
What are the 5-lipooxygenase inhibitors and what is their mechanism of action?
Zilueton
It works by inhibiting synthesis of Leukotrienes, which are involved in bronchocostrictin.
USED FOR ASTHMA
Name the Leukotriene antagonists and their MOA..
Montelukast
Zafirlukast
They work by competitively inhibiting leukotrienes.
Zafir climbs the mountain to look
What are the four Corticosteroids and how do they work?
Prednisone, Hydrocortisone, Dextramethasone, Prednisone
They work by entering the cell, binding to receptors, entering the nucleus and suppressing transcription
What is the significance of Lipocortin?
It suppresses the action of phospholipase A2. Corticosteroids increase Lipocortin to stop production of A.A.
What are the calcineurin inhibitors and their MOA
They are Cyclosporin and Tacrolimus– they inhibit t-cell production via APC pathway
Wha are the toxicities of calcineurin inhibitors?
non-hogdkin lymphoma .
What does -Ib indicate
inhibitor
Which drug inhibits signaling through IL-2 pathway?
Tofacitenib— it works by ihnbiting JAK stat pathway than that is stimulated by IL2
Name the anti-TNF antibody drugs and their MOA.
Etancercept(mab-like), Infliximab, Adalimumbab. They are cytokine antibodies, attached directly the cytokines.
Name the anti-IL5 drugs..
Mepolizumab, used for eosinophilic asthma
Name the anti IL6 dugs…
Tocilizumab
Which drugs inhibit purine synthesis?
Azathioprine- associated with cancer!!!!
Mycophenolate – they are a similar structure and are incorporated into DNA chain
What is Methotrexate’s MAO?
competitive inhibitor of folate, binds to DHFR, inhibits folic acid snythesis, inhibits purine synthesis, inhibits DNA synthesis —–
NOT BE USED WITH PREGNANT WOMEN
What is DHFR?
Dihydrofolate reductase
What are the three drugs that should not be used in pregnancy?
Azathioprine, Mycophenolate, Methotrexate
What class of drug is Sirolimus and the MOA ?
KNOW THIS
It is a mTor inhibitor
- block IL-2 pathway (m-tor) therefore suppressing t-cell proliferation
What doe Rituximab target?
CD20 B-cell receptor
What drug binds to the IL-1 receptor?
Anakinra
Which drug has decreased absoroption in older patients
Mycophenolate, tacrolimus, prednisone
Name the drugs that are used in supressing the rejection of organs?
Cyclosporin, Tacrolimus, Azathiprine, Sirolumus, Rituximab
Which drugs are associated with non-hodgekins lymophoma
The calcineurin inhibitors- cyclosporin and tacrolimus
What is the function of Sirolumus
It is an Mtor inhibitor
Name the drugs that suppresses IL-6, and what class it falls in:
Tocilizumab, antibodies
Which drugs are associated with nephrotoxicities?
Cyclosporin and Tacrolimus
Which drug kinds to the CD20 receptor?
Rituximab
What is the IL-6 binding antibody?
Tocilizumab
