Humoral Immunity Flashcards
What cytokines activates NK cell production?
IL-12 and INF gamma
Which cytokine activates b-cells?
IL-6
Describe the process by which T-cells help stimulate B-cell :
1) B-cells ingest antigen
2) B cells display antigen on cell in MHC receptor
3) T helper cell recognize and attach, releasing cytokines and causing b-cell proliferation
What is the first antibody made my a b-cell?
Ig-M
What antibody recognized the antigen?
IgM
Do antibodies bind tightly or loosely to the antigen ?
tightly
At what stage of v-cell maturation does recombination happen
Pre-B cell
What is the cell type that is released from the bone marrow?
Mature b cell with IgM and IgD receptors
What is the binding region of the antibody called?
Fab region
What is the non-binding region of the antibody?
The Fc region
Which cells have Fc region receptors that allow for antibodies to bind?
macrophage, neutrophils, eosinophils, NK cells, mast cells
What is the function on IgG?
V important for bacterial and viral infections.
- Most common
- Only one that cross placenta
Which antibody is made first to infections?
IT IS THE LARGE PENTAMER iGM!!!!
Which antibodies respond to allergic reactions?
IgE!!!
What are the most common mature b-cells usually found, and what is another name from them?
The are also called Follicular B cells because they are found in the lymph node and spleen follicles
