Immunosuppressants

Question 1

How do glucocorticoids work?

Answer 1

These work by inhibiting transcription of inflammatory cytokines.

Also alters ion transport resulting in immunosupression.

Question 2

What is a high dose of glucocorticoids?

Answer 2

> 30 mg but less than 100 mg prednisone equivalent per day.

Question 3

What is a medium dose of glucocorticoids?

Answer 3

This is >7.5 mg but less than 30 mg prednisone per day.

Question 4

Cyclosporine and Tacrolimus are both drugs used for what specific medical function?

Answer 4

Both drugs used specifically for transplantation and are immunosupressants.

Question 5

What is Azathioprine metabolized into?

Answer 5

This drug is metabolized into 6-MP.

Question 6

What is the primary NSAID used to treat gout?

Answer 6

Indomethacin!

Has largely replaced colchicine as the drug of choice.

Question 7

How does Allopurinol work?

Answer 7

Allopurinol is a xanthine oxidase inhibitor that is used to treat gout by lowering uric acid concentration.

Question 8

How do the drugs probenecid and sulfinypyazone help to treat gout?

Answer 8

These work to increase renal clearance of uric acid by inhibiting the proximal tubular reabsorption.