Immunosuppresants and Therapeutic Abs

Question 1

Cyclosporine

Answer 1

Calcineurin inhibitor, binds cyclophilits blocking T cells activation by prevention transcription of IL2

Question 2

Tacrolimus

Answer 2

Calcineurin inhibition through binding of FK506 blocking T cell activation by preventing transcription of IL2

Question 3

Sirolimus (Rapamycin)

Answer 3

Blocks transcription of IL2 by binding MTOR inhibiting T cell activation and B cell differentiation

Question 4

Basiliximab

Answer 4

Anti-IL2R

Question 5

Azathioprine

Answer 5

Precursor of 6MP, inhibits proliferation by preventing synthesis of purines

Question 6

Mycophenolate mofetil

Answer 6

Reversibly inhibits IMP deydrogenase preventing purine synthesis of B and T cells

Question 7

Corticosteroids

Answer 7

Inhibit NFKB suppressing B and T cell function, decreasing cytokine production, and promoting apoptosis

Question 8

Alemtuzumab

Answer 8

Anti-CD52, used in CLL and MS

Question 9

Bevacizumab

Answer 9

Anti-VEGF, various carcinomas

Question 10

Cetuximab

Answer 10

Anti-EGFR, stage 4 colorectal cancer

Question 11

Rituximab

Answer 11

Anti-CD20, NHL, CLL, RA, ITP

Question 12

Trastuzumab

Answer 12

HER2/neu, Breast and gastric cancer

Question 13

Adalimumab

Answer 13

Anti TNFa

Question 14

Infliximab

Answer 14

Anti TNFa

Question 15

Daclizumab

Answer 15

Anti CD25

Question 16

Eculizumab

Answer 16

Anti- Complement C5

Question 17

Natalizumab

Answer 17

a4-integrin

Question 18

Ustekinumab

Answer 18

Anti IL-12/IL23

Question 19

Abciximab

Answer 19

Anti GPIIb/IIIa

Question 20

Denosumab

Answer 20

Anti RANKL

Question 21

Digoxin immune Fab

Answer 21

Anti Digoxin

Question 22

Palivizumab

Answer 22

Anti RSV F Protein

Question 23

Ranivizumab

Answer 23

Anti VEGF