Immunopathology (part 1) Flashcards
how many lines of defense do we have? name them
3 lines
-mechanical/chemical barrier
-innate immunity
-adaptive immunity
true or false
innate immunity is specific
false – nonspecific
adaptive immunity is specific
what is the myeloid stem cell
pluripotent stem cell that can produce lot of WBC
what is the primary antigen presenting cell
MACROPHAGES
macrophages express MHC class 1 or 2 molecules
CLASS 2
what does the lymphoid stem cell produce
T lymphocyte
NK lymphocyte
B lymphocyte (becomes plasma cell)
_______ are the key components of the acquired immune system
lymphocytes (T and B lymphocytes)
CD4 t cells express MHC class _____ and CD8 T cells express MHC class ____
(way of recognizing antigens)
CD4 = MHC type 2
CD8 = MHC type 1
MHC class ___ is recognized by natural killer cells
class 1
MHC class 2 is expressed on what cells
antigen presenting cells
name 3 antigen presenting cells
macrophages
dendritic cells
b cells
MHC Class 2 is recognized by what cells
helper t cells
what cells recognize and kill tumor and virus infected cells
natural killer cells
name 4 immune system disorders
hypersensitivity reactions (1-4)
autoimmune diseases
immune deficiency syndromes
transplantation immunity
define a hypersensitivity reaction
an exaggerated immune response that results in tissue injury
type _______ hypersensitivity reactions are dependent on the interaction of specific antibodies with the given antigen
type _____ hypersensitivity reactions recognize through antigen receptors on T cells
type 1-3 are dependent on antibody interaction with antigen
type 4 through antigen receptors on T cells
name 3 type 2 hypersensitivity reactions
myasthenia gravis - causes muscle weakness
graves disease - stimulates cells to produce more thyroid hormones
goodpasture syndrome - glomerulonephritis, or bleeding in lungs
Transfusion reaction and Rh reaction are what kind fo hypersensitivity
type 2
skin and food allergies are what hypersensitivity
type 1
which hypersensitivity is the cytotoxic type name 3 types
type 2
myasthenia graves (muscle weakness)
graves disease (too much thyoroid hormone)
goodpasture
which hypersensitivity is the immune complex typw
name 2 types
type 3
arthritis
glomerulonephritis
what hypersensitivity is the anaphylactic typw
give 4 examples
type 1
hay fever
asthma
hives
anaphylaxis
what hypersensitivity is the cell-mediated type
give 2 examples
type 4
tuberculosis (granulomatous disease) and poison ivy (delayed skin reaction)
what antibody is involved with type 1
ige antibody
