Immunology Revision

Question 1

describe innate immunity

Answer 1

• neutrophils, monocytes, macrophages, eosinophils and mast cells
• no danger of autoimmunity
• no clonal memory
• can have different receptors
• antigen receptor is directly encoded from a gene

Question 2

Describe adaptive immunity

Answer 2

• one specificity of receptor
• cells are different from one another
• antigen receptor is not directly encoded
• there is clonal expansion and memory
• there is a danger of autoimmunity
• B and T lymphocytes

Question 3

Where are B lymphocytes produced

Answer 3

bone marrow

Question 4

Where are T lymphocytes produced

Answer 4

Thymus

Question 5

what is the difference between B and T lymphocytes

Answer 5

• B lymphocytes = antigen receptor is antibody
• B lymphocytes recognised antigens anywhere whereas T lymphocytes only when presented on the surface of another cell
• B lymphocytes - considerable secretion by plasma cell
• T lymphocytes have little or none secretion of receptor

Question 6

How does clonal deletion of B lymphocytes happen

Answer 6

• if in the bone marrow if they encounter an antigen that engages their antibody at the point when they are expressing their antibody as IgM only
• for T dependent B lymphocytes in lymph node cortex and germinal centre after activation, when they are undergoing expansion and somatic mutation if they fail to get help from CD4 T-lymphocytes