Immunology Quiz Questions

Question 1

Where would you most likely find a TLR that recognizes RNA genome of a virus particle?

Answer 1

In the membrane of the endosome/lysosome

Question 2

Which molecules are involved in Signal 1 of T cell activation?

Answer 2

• MHC/peptide
• CD3
• TCR
• CD4/CD8 are NOT involved in signal 1

Question 3

Which molecules are involved in Signal 2 of T cell activation?

Answer 3

• CD28

- B7

Question 4

Why is the bivalent nature of antigen being domains on the BCR important for Signal 1 of B cell activation?

Answer 4

BCR cross linking allows for clustering of Iga and Igb which triggers signaling to the nucleus

Question 5

In the absence of IFNy, what aspects of adaptive immune responses will be affected?

Answer 5

• increased ability of macrophages to acidity cellular vesicles and produce alarm cytokines
• B cell mediated class switch to IgG