Immunology P 209 Flashcards

1
Q

Cyclosporine MOA, SE

A

Binds to cyclophilin -> inhibits Calcineurin -> block IL2 secretion

SE: Nephrotoxic, HTN, Hyperlipidemia, Hyperglycemia, Gingival Hyperplasia, Hirsutism

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2
Q

Tacrolimus MOA, SE

A

Binds to FK-binding protein -> inhibit calcineruin -> block IL2 secretion

SE: like cyclosporine, but no Gingival Hyperplasia, Hirsutism

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3
Q

Sirolimus

A

Inhibits mTOR

SE: Hyperlipidemia, Thrombocytopenia, Leukopenia

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4
Q

Azathioprine

A

Antimetabolite of 6MP, block PRPP amidotransferase.

SE: Bone Marrow Suppression. Toxic effect increase w/ Allopurinol

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5
Q

Muromonab

A

Monoclonal Ab, binds to CD3.

SE: cytokine release syndrome.

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6
Q

Omalizumab

A

Blocks IgE

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7
Q

Oprelvekin:

A

TX thrombocytopenia

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8
Q

Thrombopoietin:

A

Tx Thrombocytopenia

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9
Q

Filgrastim:

A

G-CSF (use w/ NRTI)

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10
Q

Sargramostim:

A

GM-CSF

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11
Q

IFN-A

A

HepB/C, Kaposi sarcoma, RCC, leukemias/lymphomas

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12
Q

IFN-B

A

MS

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13
Q

IFN-Gamma

A

CGD

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