Heme Pharm p. 367 Flashcards
Heparin or Warfarin: Use in pregnancy (why? molecular structure)
Heparin can be used in pregnancy b/c it is large, anionic acidic polymer.
Warfarin: Small, lipid soluble molecular that passes placenta
Antidote to tPA
Aminocaproic acid
ADP receptor inhibitors (4)
Clopidogrel, TIclopidine, Prasugrel, Ticagrelor
Cilostazol and Dipyridamole? MOA, Use, SE
PDE3 inhibitor -> increase cAMP -> inhibit platelet aggregration.
USE: intermittent claudication, CORONARY VASODILATION, prevention of stroke/TIA. ANGINA prophylaxis
SE: N, HA, Flushing, Hypotension, Ab pain
3 GPIIB/IIIA inhibitors
Abciximab, Eptifibatide, Tirofiban
What cancer drugs acts during G2?
Bleomycin
MTX: MOA and SE
BLock DHR,
SE: macrovasicular fatty change in liver
Mucositis
5FU: MOA and SE
bioactivated to 5F-dUMP -> inhibits thmidylate synthase.
SE: Photosensitivity
Rescue w/ Thymide
Cytarabine: MOA, SE
Pyrimidine analog -> block DNA polymerase
SE: megalobastic anemia
What drug has toxicity w/ allopurinol?
6MP -> purine synthesis
When do you use Dactinomycin? MOA
KIDS -> Ewing sarcoma, Wilm, Rhabomyosarcoma
MOA: intercalates DNA
Doxorubicin MOA, SE, Rescue?
MOA: generates free radicals and intercalates -> breaks DNA
SE: cardiotoxic
Rescue: Dextrazonane
Bleomycin MOA, USE, SE
Generates ROS -> breaks DNA strands
Use: Testicular cancer, Hodgkin
SE: Pulm fibrosis, skin changes, NO myelosuppression
Drug a/w TCC?
Cyclophosphamide, Use Mensa to bind to accrolein toxic compounds
Bursulfan: MOA, Use, SE
Alkylates DNA
USE: CML, Bone transplant
SE: Hyperpigmentation, Pulm Fibrosis
