Immunology MCQ Flashcards
During an immune response to viral infection in the lung, naive T cells would most likely be activated in the
A lymph node
B thymus
C site of infection
D inflamed tissue
E blood
A
On repeat exposure to a pathogen, a patient is identified with high circulating levels of IgM antibody specific for the pathogen. This is most likely caused by
A IgM levels being enhanced by natural killer cells
B IgM being the most appropriate response
C failure of CD8 T cells
D IgM levels being enhanced by complement
E a lack of isotype switching
E
Many years ago, William Coley found that injection of bacterial extracts would often clear many types of tumour. This technique was most likely successful because
A the activation of dendritic cells was enhanced by the bacterial extracts
B bacterial extracts activate complement
C cytotoxic T cells specific for proteins in the bacterial extract were generated
D the bacterial extracts were directly toxic to the tumours
E antibodies specific for proteins in the bacterial extract were generated
A
Which immune component is primarily involved in the development of serum sickness?
A IgA
B IgG
C IgM
D IgE
E CD8 T cells
B
A typical function performed by dendritic cells is
A release of histamine during allergies
B perforin-mediated cytolytic activity
C phagocytosis
D antigen-specific neutralisation
E antibody dependent cytotoxicity
C
Which of the following patients is likely to have a primary immunodeficiency? A patient
A lacking T cells after HIV infection
B lacking T cells after an organ transplantation
C lacking T cells due to a mutation in major histocompatibility complex (MHC) genes
D with severe burns
E lacking T cells after radiotherapy for treatment of cancer
C
A viral infection lowers the level of major histocompatibility complex (MHC) I at the cell surface, leaving all other surface molecules unchanged. The immune cell type that will likely be activated by this change on the infected cell is the
A CD8 T cell
B natural killer (NK) cell
C CD4 T cell
D macrophage
E neutrophil
B
A patient receives an infusion of antibody to neutralise the effect of the venom after a snake bite. The treatment is successful, but 7-14 days later the patient develops a fever. The cause of this fever is most likely due to
A the foreign source of the antibody
B antibody-mediated mast cell degranulation
C the antibody failing to completely neutralise the venom
D reactivation of the venom
E antibody-dependent cell mediated cytotoxicity
A
The classical complement pathway is activated by
A components of the innate immune system
B components of the adaptive immune system
C cytokines
D chemokines
E components of the clotting cascade
B (a)?
During an immune response, isotype switching can be described as
A the switch from IgM production to IgG, IgA or IgE production
B a switching process for the T cell receptor genes that occurs in T cell development
C the switching of peptides from the MHC class I pathway to the MHC class II pathway
D the switching of a CD4 Th1 response to a CD4 Th2 response
E the switching of different immunoglobulin light chains
A
Researchers were attempting to create a new vaccine based on the induction of protective antibody responses against extracted lipids from the bacterial cell wall. To their surprise, no antibodies were induced after injection of the lipid extracts into mice. The lack of antibody was most likely because
A dendritic cells cannot carry lipids to the lymph node or spleen
B B cells do not produce antibodies against lipids
C there was no source of foreign protein in the injection to invoke a CD4 T cell response
D only a T cell response will be induced by lipids
E lipids are only recognised by innate immune cells
C
Recognition of peptide / MHC I and induction of apoptosis in virally infected cells is usually attributed to which immune cell type?
A Macrophages
B CD8 T cells
C CD4 T cells
D B cells
E dendritic cells
B
Which one of the following factors is an opsonin? .
A interleukin 4 (IL-4)
B granzymes
C interleukin 6 (IL-6)
D complement
E perforin
D
Delayed type hypersensitivity (DTH) is characterised by
A mast cell degranulation after IgE crosslinking
B IgG antibody reactivity against penicillin-coated platelets
C a T cell-mediated immune response
D IgG antibody reactivity against cell surface receptors
E immune complexes of antibody and antigen
C
The primary immune response to a bacterial infection is characterised by which isotype of immunoglobulin?
A IgA
B IgD
C IgE
D IgG
E IgM
E
