Immunology High Yields Flashcards
CD2
T Cell
CD3
T Cell
CD4+
Helper T Cell
CD8+
CTLS
CD28
Binds B7 on APC
T cells
CD40L
Binds CD40 to activate B cells or macrophages
T Cells
TCR
T Cells
CD19
B Cells
CD20
B Cells
CD21
B Cells
CD40
Binds CD40L
B Cells
Macrophages
B7
Binds CD28
B Cells
Macrophages
MHC Class I and II
B cells (both) Macrophages (both) NK cells (MHC I only)
CD14
Macrophages (endotoxin receptor)
CD16
Macrophages (Fc-gamma) receptor
NK Cells
CR1
Macrophages (C3b receptor)
CD56
NK Cells
CD55
RBCs, WBCs, Platelets
CD59
RBCs, WBCs Platelets
X-Linked Immunodeficiencies
"Missing WBCs" Hyper-IgM, Wiscott-Aldrich syndrome, Burton's agammglobulinemia, Chronic grandulomatous disease, Severe combined immunodeficiency
Anaphylactic Reaction Following Blood Transfusion
IgA deficiency
IgE against Fc portion of IgA heavy chain
HLA-A3
Hemochromatosis
HLA-B27
Psoriatic arthritis, Ankylosing spondylitis, Inflammatory bowel disease arthritis, Reactive arthritis (Reiter syndrome)
HLA-DQ2/DQ8
Celiac disease
HLA-DR2
MS, hay fever, SLE, Goodpasture
HLA-DR3
Diabetes mellitus type 1, SLE, Graves, Hashimoto
HLA-DR4
Rheumatoid arthritis, diabetes mellitus type 1
HLA-DR5
Pernicious anemia–> B12 deficiency; Hashimotos
IL-1
Secreted by macrophages
Fever, acute inflammation; Activates endothelium to express adhesion molecules; Induces chemokine secretion to recruit WBCs
IL-6
Secreted by macrophages
Fever, stimulates production of acute phase proteins
IL-8
Secreted by macrophages
Major chemotactic factor for neutrophils
“Clean up in aisle 8”
IL-12
Secreted by macrophages
Induces differentiation of T cells into Th1 cells; Activates NK cells
TNF-alpha
Secreted by macrophages
Mediates septic shock; Activates endothelium; Causes WBC recruitment; Vascular leak; Causes cachexia in malignancy
IL-2
Secreted by all T cells
Stimulates growth of helper, cytotoxic and regulatory T and NK cells
IL-3
Secreted by all T cells
Supports growth and differentiation of bone marrow stem cells; Functions like GM-CSF
Interferon-gamma
Secreted by Th1 cells
Secreted by NK cells in response to IL-12 from macrophages; Stimulates macrophages to kill phagocytosed pathogens; Also activates NK cells to kill virus infected cells; Increases MHC expression and antigen presentation by all cells
IL-4
Secreted by Th2 cells Induces differentiation into Th2 cells; Promotes growth of B cells; Enhances class switching to IgE and IgG
IL-5
Secreted by Th2 cells Promotes differentiation of B cells; Enhances class switching to IgA; Stimulates growth and differentiation of eosinophils
IL-10
Secreted by Th2, Treg cells
Modulates inflammatory response; Decreases expression of MHC class II and Th1 cytokines; Inhibits activation of macrophages and dendritic cells;
Attenuate immune response
TGF-beta
Attenuates immune response
T Cell Proteins
TCR, CD3 (associated with TCR for signal transduction), CD28 (binds B7 on APC)
Helper T Cell Proteins
CD4, CD40L
Cytotoxic T Cell Proteins
CD8
Regulatory T Cell Proteins
CD4, CD25
B Cell Proteins
Ig (binds antigen); CD19, CD20, CD21 (receptor for EBV), CD40, MHC II, B7
“you can drink beer at the bar when you are 21” - EBV receptor is CD21
Macrophage Proteins
CD14 (binds LPS), CD40, MHCII, B7, Fc and C3b receptors (enhance phagosytosis)
NK Proteins
CD16 (binds Fc of IgG), CD56 (unique marker)
Hematopoietic Stem Cell Proteins
CD34
