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FA 2015 High Yields > Immunology High Yields > Flashcards

Immunology High Yields Flashcards

1
Q

CD2

A

T Cell

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2
Q

CD3

A

T Cell

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3
Q

CD4+

A

Helper T Cell

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4
Q

CD8+

A

CTLS

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5
Q

CD28

A

Binds B7 on APC

T cells

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6
Q

CD40L

A

Binds CD40 to activate B cells or macrophages

T Cells

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7
Q

TCR

A

T Cells

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8
Q

CD19

A

B Cells

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9
Q

CD20

A

B Cells

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10
Q

CD21

A

B Cells

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11
Q

CD40

A

Binds CD40L
B Cells
Macrophages

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12
Q

B7

A

Binds CD28
B Cells
Macrophages

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13
Q

MHC Class I and II

A 
B cells (both)
Macrophages (both)
NK cells (MHC I only)
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14
Q

CD14

A

Macrophages (endotoxin receptor)

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15
Q

CD16

A

Macrophages (Fc-gamma) receptor

NK Cells

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16
Q

CR1

A

Macrophages (C3b receptor)

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17
Q

CD56

A

NK Cells

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18
Q

CD55

A

RBCs, WBCs, Platelets

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19
Q

CD59

A

RBCs, WBCs Platelets

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20
Q

X-Linked Immunodeficiencies

A 
"Missing WBCs" 
Hyper-IgM, 
Wiscott-Aldrich syndrome, 
Burton's agammglobulinemia, 
Chronic grandulomatous disease, 
Severe combined immunodeficiency
21
Q

Anaphylactic Reaction Following Blood Transfusion

A

IgA deficiency

IgE against Fc portion of IgA heavy chain

22
Q

HLA-A3

A

Hemochromatosis

23
Q

HLA-B27

A

Psoriatic arthritis, Ankylosing spondylitis, Inflammatory bowel disease arthritis, Reactive arthritis (Reiter syndrome)

24
Q

HLA-DQ2/DQ8

A

Celiac disease

25
Q

HLA-DR2

A

MS, hay fever, SLE, Goodpasture

26
Q

HLA-DR3

A

Diabetes mellitus type 1, SLE, Graves, Hashimoto

27
Q

HLA-DR4

A

Rheumatoid arthritis, diabetes mellitus type 1

28
Q

HLA-DR5

A

Pernicious anemia–> B12 deficiency; Hashimotos

29
Q

IL-1

A

Secreted by macrophages
Fever, acute inflammation; Activates endothelium to express adhesion molecules; Induces chemokine secretion to recruit WBCs

30
Q

IL-6

A

Secreted by macrophages

Fever, stimulates production of acute phase proteins

31
Q

IL-8

A

Secreted by macrophages
Major chemotactic factor for neutrophils
“Clean up in aisle 8”

32
Q

IL-12

A

Secreted by macrophages

Induces differentiation of T cells into Th1 cells; Activates NK cells

33
Q

TNF-alpha

A

Secreted by macrophages

Mediates septic shock; Activates endothelium; Causes WBC recruitment; Vascular leak; Causes cachexia in malignancy

34
Q

IL-2

A

Secreted by all T cells

Stimulates growth of helper, cytotoxic and regulatory T and NK cells

35
Q

IL-3

A

Secreted by all T cells

Supports growth and differentiation of bone marrow stem cells; Functions like GM-CSF

36
Q

Interferon-gamma

A

Secreted by Th1 cells
Secreted by NK cells in response to IL-12 from macrophages; Stimulates macrophages to kill phagocytosed pathogens; Also activates NK cells to kill virus infected cells; Increases MHC expression and antigen presentation by all cells

37
Q

IL-4

A 
Secreted by Th2 cells
Induces differentiation into Th2 cells; Promotes growth of B cells; Enhances class switching to IgE and IgG
38
Q

IL-5

A 
Secreted by Th2 cells
Promotes differentiation of B cells; Enhances class switching to IgA; Stimulates growth and differentiation of eosinophils
39
Q

IL-10

A

Secreted by Th2, Treg cells
Modulates inflammatory response; Decreases expression of MHC class II and Th1 cytokines; Inhibits activation of macrophages and dendritic cells;
Attenuate immune response

40
Q

TGF-beta

A

Attenuates immune response

41
Q

T Cell Proteins

A

TCR, CD3 (associated with TCR for signal transduction), CD28 (binds B7 on APC)

42
Q

Helper T Cell Proteins

A

CD4, CD40L

43
Q

Cytotoxic T Cell Proteins

A

CD8

44
Q

Regulatory T Cell Proteins

A

CD4, CD25

45
Q

B Cell Proteins

A

Ig (binds antigen); CD19, CD20, CD21 (receptor for EBV), CD40, MHC II, B7
“you can drink beer at the bar when you are 21” - EBV receptor is CD21

46
Q

Macrophage Proteins

A

CD14 (binds LPS), CD40, MHCII, B7, Fc and C3b receptors (enhance phagosytosis)

47
Q

NK Proteins

A

CD16 (binds Fc of IgG), CD56 (unique marker)

48
Q

Hematopoietic Stem Cell Proteins

A

CD34

FA 2015 High Yields (10 decks)

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