immunology - cytokines

Question 1

what is the main source and function of IL-1

Answer 1

main source = macrophages

function = acute inflammation and induces fever

Question 2

what is the main source and function of IL-2

Answer 2

main source = Th1 cells

function = stimulates growth and differentiation of T cell response

Question 3

what is the main source and function of IL-3

Answer 3

main source = activated T helper cells

function = stimulates differentiation and proliferation of myeloid progenitor cells

Question 4

what is the main source and function of IL-4

Answer 4

main source = Th2 cells

function = stimulates proliferation and differentiation of B cells

Question 5

what is the main source and function of IL-5

Answer 5

main source = Th2 cells

function = stimulate the production of eosinophils

Question 6

what is the main source and function of IL-6

Answer 6

main source = macrophages and Th2 cells

function = stimulates differentiation of B cells and induces fever

Question 7

what is the main source and function of IL-8

Answer 7

main source = macrophages

function = neutrophil chemotaxis

Question 8

what is the main source and function of IL-10

Answer 8

main source = Th2

function = inhibits TH1 cytokine production also known as human cytokine synthesis inhibitory factor and is an anti-inflammatory cytokine

Question 9

what is the main source and function of IL-12

Answer 9

main source = dendritic cells, macrophages, B cells

function = activates NK cells and stimulates differentiation of naive T cells into Th1 cells

Question 10

what is the main source and function of tumour necrosis factor alpha

Answer 10

main source = macrophages

function = induces fever and neutrophil chemotaxis

Question 11

what is the main source and function of interferon-gamma

Answer 11

main source = Th1 cells

functions = activates macrophages