Immunology CH 3.6 Igs, Complement ande Cellular Testing

Question 1

which of the following symptoms in a young child may indicate an immmunodeficiency sydrome?

anaphylactic rxn
severe rashes and myalgia
reccurent bacterial, viral and fungal infections
weightt loss, rapid heart, SOB

Answer 1

C, recurrent infections

Question 2

what screening test should be preformed first in a young pt suspected of having immune dysfunction disorder?

CBC and WBC diff
chemotaxis assay
complement levels
bone marrow biopsy

Answer 2

CBC and Diff

Question 3

which test should be performed when a pt has a rxn to a transfused plasma product?

Ig levels
T cell count
hemoglobin levels
RBC enzymes

Answer 3

Ig levels

Question 4

What is the M component in monoclonal gammopathies?

IgM produced in excess
heavy chain produced in excess
malignant proliferation of B cells
monoclonal ab or cell line

Answer 4

Monoclonal ab or cell line

Question 5

A child is suspected of a humoral immunodeficiency, two weeks after immunization w TdAP his level of specific ab is measured. what would these levels be if he had a true deficiency?

increased levels of deficiency
no change in levels
an increase in IgG specific antibody but not IgM specific antibody
increased levels of nonspecific antibody

Answer 5

B: no change in levels

Question 6

which disease may be expected to show an IgM spike on electrophoretic pattern?

hyogammaglobulinemia
multicystic kidney disease
waldenstrom macroglobulinemia
wiskot aldrich syndrome

Answer 6

WM

Question 7

in testing for Degorge sydrome, what type of lab analysis would be most helpful in determining the number of mature t cells?

CBC
DHR (dihydrorhodamine reduction) test
T cell mitogen assay
flow cytometry

Answer 7

flow cytometry

Question 8

interpret the IFE urine assay: dense wide bands in both kappa and lamba lanes, no bands in the heavy chain lanes.

normal
light chain disease
increased polyclonal Fab fragments
Multiple myeloma

Answer 8

increased polyclonal fab fragments

Question 9

free monoclonal light chains are often present in serum of pts with MM and may be used for monitoring. Which test would be used to detect levels of free light chains in serum?

SPE
Urine immunofixation
nephelonetry
ELISA

Answer 9

nephelometry

Question 10

What is measureed in the CH50 assay?

RBC quantity to agglut 50% of ab
complement needed to lyse 50% of RBCS
complement needed to lyse 50% of ab sensitized RBCs
antibody and compliment needed to sensitize 50% of RBCS

Answer 10

complement needed to lyse 50% of ab sensitized rbcs

Question 11

what type of disorder would show a decrease is C3,C4 and CH50?

autoim disorders like SLE and RA
imm def disorders like variable immunodef
tumors
bacterial,fungal,parasitic infections

Answer 11

autoimmune disorders like SLE nad RA

Question 12

all the following tests measuer phagocytic function except?

Leukocyte adhesion molecule analysis
DHR assay
Nitro blue tetrazolium (NBT) test
IL-2 assay

Answer 12

IL-2 assay