Immunology CH 3.5 Hypersensitivity Flashcards
which of the following is a description of a type 1 hypersensitivity reaction?
ragweed ag cross linked with IgE on mast cells, causes release of mediators and results in symtoms of an allergic rxn
anti fya from preg woman crosses placents..etc
immune complex desposition in basement membrane of kidney leading to renal failure
exposure to poision ivy causes t cells to release lymphokines that cause localized inflamm rxn
A, immediate hypersensitivity response
why is skin testing the most widely used method to test for a type 1 hypersensitivity reaction?
it causes less trauma and is more cost effective
it has greater sensitivity than in vitro measurements
it is more likely to be positive for IgE specific allergens than other methods
it may be used to predict the development of further antigen sensitivity
skin testing is much more sensitive than other testing
which in vitro test measures IgE levels against a specific allergen?
histamine relase assay
radioimmunosorbent assay (RIST)
fluorescnet allergosorbent test (FAST)
precipitin radioimmunosorbent test (PRIST)
C, FAST
A type O pt is transfused A type blood and develops a reaction. what antibody is involved in this type II reaction?
IgM
IgE
IgG and IgE
IgG
IgM
Which test would measure the coating of RBCs by antibody as occurs in hemolytic transfusion reactions?
Indirect Antiglobulin test (IAT)
Direct antiglobulin test (DAT)
ELISA
Hemagglutination
DAT
which test detects antibodies that have attached to tissues, resulting in a type II cytotoxic reaction?
indirect immunoflourescence
direct immuno… (DIF)
immunofixation electrophoresis (IFE)
Hemagglutination
Direct immunoflourescence (DIF)
which of the following conditions will most likely result in a false negative DAT test?
insufficient washing of RBCs
use of heavy chain-specific polyclonal antihuman Ig
use of eccessive centrifuge force
use of sample by finger puncture
insufficent washing of RBCS
which of the following tests will detect circulating immune complexes in the serum of some patients with systemic autoimmune diseases such as RA?
Direct IFA
enzyme immunoassay EIA
assay of cryoglobulins
IAT
Assay of cryoglobulins
what immune elements are involved in a positive skin test for TB?
IgE ab
T cells and macrophages
NK cells and IgG ab
B cells and IgM ab
T cells and macrophages
a pt receives a transfusion of PRBCS and FFP and develpoes and anaphyacic non hemolytic reaction. She reports receiving a transfusion 20 yrs ago. She had no rxn to the previous transfusion but felt poor afterwards. What is the most likely substance eliciting the reaction?
IgA
group A ag
Rho (D) antigen
an antigen belonging to the Duffy system
IgA
A pt deficient in the C3 compliment component would be expected to mount a normal:
Type I and IV hypersensitivity response
Type II and IV hypersensitivity response
Type I and III hypersensitivity response
Type II and III hypersensitivity resposne
Type I and IV hypersensitivity
