Immunology/Allergology

Question 1

chromosomal region comprises several genes implicated in allergic disease pathogenesis

Answer 1

5q23-35

Question 2

Diagnosis of allergic rhinitis is established by what age?

Answer 2

6 yo

Question 3

Mnemonics: DiGeorge Syndrome

Answer 3

CATCH-22

Cardiac defect (TOF) 
Abnormal facies 
Thymic aplasia 
Cleft palate 
Hypocalcemia

Question 4

Mnemonics: Wiskott-Aldrich syndrome

Answer 4

How do you TIE a WASP?

Thrombocytopenia
Infections
Eczema
WASP mutation

Question 5

chr 5p13, 10p13, 11p13, 1q31-q32

Answer 5

SCID

Question 6

chr Xp 11.4-11.21

Answer 6

Wiskott-Aldrich Syndrome

Question 7

chr 17q21.3

Answer 7

Hyper IgE syndrome (AD or sporadic or Job syndrome)

Question 8

chr 21q22.3

Answer 8

Hyper IgE syndrome (AR)

Question 9

absence of T and B cell function

Answer 9

SCID

Question 10

T cell def, poor Ab production to polysaccharides

Answer 10

Wiskott-Aldrich Syndrome

Question 11

Coarse facies, coronary artery aneurysm, mortality in adulthood, pathologic fractures

Answer 11

Hyper IgE syndrome (AD or sporadic or Job syndrome)

Question 12

higher incidence of lymphomas; skin CA, mortality in childhood

Answer 12

Hyper IgE syndrome (AR)