Immunology Flashcards
Which type of immunity forms immunological memory?
Adaptive
When is the immediate innate immune response begun in response to a pathogen?
0-4 hours
When is the early innate immune response begun in response to a pathogen?
4-96 hours
When is the late adaptive immune response begun in response to a pathogen?
> 96 hours
What aspects of innate immunity does the skin not have? What aspects does it have?
No physical barrier or commensal bacteria. There are chemical agents and immunological cells present.
What enzyme is found in tears which is an important chemical barrier?
Lysozyme
What 3 cells are found in tears which are important in the immune response?
Neutrophils, macrophages and conjunctival mast cells
What is the function of conjunctival mast cells?
Vasoactive mediators
What 3 things does the adaptive immune system require?
Antigen presenting cells, lymphatic drainage, variety of effector cells
What are 3 examples of antigen presenting cells?
Dendritic cells, B cells, macrophages
What are the principle antigen presenting cells in the eyes?
Langerhans cells
Langerhans cells are rich in what type of MHC molecule?
Class II
Where are Langerhans cells most abundant? Where are they absent?
Most abundant at the cornel-scleral limbus, absent from the central 1/3rd of the cornea
What is the only part of the eye with lymphatic drainage?
Conjunctiva
What three cell types of always present in MALT? What 2 cell types are present only if they are recruited?
Always present are macrophages, mast cells and Langerhans cells. Neutrophils and eosinophils are present only if they are recruited.
