Immunology 4 Flashcards
How is adalimumab different from other TNFs?
Blocks the receptor directly rather than binding the free cytokine
With regards to MS
Giving IFN beta–>
Giving IFN gamma–>
Blocking TNF alpha–>
Giving IFN beta–> good
Giving IFN gamma–> exac
Blocking TNF alpha–> worse
IFN alpha
IFN beta
IFN gamma
do what from what
alpha from leukocytes- used in hep B C
beta from fibroblasts- reduce number relapses in MS
gamma from NK and lymphocytes- modulate macrophage function
NK cells kill how
REcognise if there is MHC1 in virally infected cell and ADCC
Recognise loss MHC1 in tumour cell
Use perforins and granzymes
CD8 do the same
How do neutrophils kill
oxygen burst
how do eosinophils kill
release granzymes into environment
Desens to pollen does what
Asthma modest benefit
Good for allergic rhinitis
Three types of chronic rhinosinusitis
- with polyps- assoc with aspirin and NSAID
- allergic fungal - assoc with specific IgE; allergic reaction to colonising fungal infection
- chronic rhinosinusitis without polyps-most; assoc asthma, smoking, immunodef incl IgA, mucociliary, immunodef, systemic diseases etc.
what cell type is low in CVID
absent memory B cells in 80% !
Can you desensitise people to their severe peanut allergies with skin testing?
no
Metformin reduces NETs= neutrophil extracellular traps- why good>
IN lupus increases apoptosis and reduces/defective clearance disease–>release self DNA–>formation nucleic acid immune complexes
TSH aim in pregnancy in thyrotoxicosis
under 2.5 pre conception and T1
under 3 in T2,T3
Replace testosterone in a 65 year old male, what is the most likely thing to happen?
Increase in lean body mass
Which test is most likely to be abnormal in a 60 year old woman with a 1.2 cm adrenal incidentaloma
1mg overnight DST
